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Jiang, B., Zhao, X.L., Dong, J.J. and Wang, W.J. (2009) Catalytic Asymmetric Oxidation of Heteroaromatic Sulfides with tert-Butyl by Droperoxide Catalyzed by a Titanium Complex with a New Chiral 1,2-Diphenylethane-1,2-diol Ligand. European Journal of Organic Chemistry, 2009, 987-991.
http://dx.doi.org/10.1002/ejoc.200801139

被以下文章引用:

• 标题: S-泮托拉唑的研究进展Recent Progress in Preparation of S-Pantoprazole

  作者: 王婷, 曾银凤, 彭丽君, 王红丹, 朱槿, 黄晴菲, 王启卫

  关键字: 泮托拉唑, 手性拆分, 不对称氧化Pantoprazole, Chiral Resolution, Asymmetric Oxidation

  期刊名称: 《Journal of Organic Chemistry Research》, Vol.3 No.4, 2015-12-28

  摘要: 泮托拉唑是一种抑制胃酸分泌的质子泵抑制剂。临床研究表明，与消旋体及其对映体相比，S-泮托拉唑抑酸效果好，生物利用度高，毒副作用低。目前报道的制备S-泮托拉唑的方法主要是手性拆分和不对称氧化。本文简要概述了S-泮托拉唑的制备研究状况。 Pantoprazole is one of the blockbuster gastric proton pump inhibitors (PPIs). The clinical study showed that S-pantoprazole provides better acid control, higher bio-availability and lower side effects compared to the racemic pantoprazole and R-panto-prazole. It is reported that the optical pure S-pantoprazole could be prepared by chiral resolution and catalytic asymmetric oxidation. This review briefly described the deve-lopment of the preparation method for the optically pure S- pantoprazole.