标题:
盐酸文拉法辛的合成Synthesis of Venlafaxine Hydrochloride
作者:
朱园园, 李婷婷, 古双喜
关键字:
盐酸文拉法辛, 合成, 抗抑郁药, 茴香醇Venlafaxine Hydrochloride; Synthesis; Antidepressant; Anisic Alcohol
期刊名称:
《Studies in Synthetic Chemistry》, Vol.1 No.1, 2013-10-08
摘要:
以廉价易得的茴香醇为原料，经7步反应以56.7%的总收率合成得到盐酸文拉法辛。该路线简捷高效，反应条件温和，后处理操作简单，适合工业化生产。
Venlafaxine hydrochloride was synthesized via 7-step reactions in the total yield of 56.7% from anisic alcohol. The synthetic route is concise and efficient, and suitable for industrialization due to its mild reaction conditions and simple post-treatment.