标题:
中药及其有效成分对血脑屏障作用的研究进展Research Progress of the Effects of Traditional Chinese Medicine and Its Active Ingredients on the Blood Brain Barrier
作者:
顾泉琳, 贝伟剑
关键字:
血脑屏障, 中药, 有效成分Blood-Brain Barrier; Traditional Chinese Medicine; Active Ingredients
期刊名称:
《Pharmacy Information》, Vol.2 No.2, 2013-05-28
摘要:
血脑屏障是大脑脉管系统维持脑组织环境和功能稳定的重要特性。脑毛细管内皮细胞间的紧密连接(TJ)是血脑屏障的结构基础，它由跨膜蛋白、胞浆粘附蛋白和连接黏附分子及细胞骨架蛋白等共同组成，维持脑毛细血管内皮机械屏障和通透性。中药对多种脑源性疾病具有良好的疗效，这与中药有效成分透过血脑屏障或改善血脑屏障的形态结构和功能有关。The blood brain barrier (BBB) is the important characteristic of the cerebral vasculature for maintaining the homeostasis of the brain environment and its function. The tight junctions (TJs) closely connecting the brain capillary endothelial cells (TJ) are the structural basis of BBB, which are composed of a transmembrane protein, intracellular adhesion protein and junctional adhesion molecules and cytoskeletal proteins, maintaining the brain capillary endothe-lial barrier and permeability. Traditional Chinese medicine (TCM) has excellent curative effect on various brain diseases, which might owe to the permeance of their active ingredients through the BBB and their effects of improving the morphological structure and function of the BBB.