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附录
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[39]
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如图1所示,与SO组相比,IBD组血清TNF-α (a)、内毒素(b)、IL-6 (c)含量显著高于SO组。与IBD组相比,SLBZS组血清TNF-α (a)、IL-6 (b)、内毒素(c)含量降低。以平均值 ± 标准差(n = 8)表示。IBD组与SO组比较,*P < 0.05、**P < 0.01;SLBZS组与IBD组比较#P < 0.05、##P < 0.01。
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[40]
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Figure 1. Inflammatory factor index
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[41]
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图1. 炎症因子指标
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[42]
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如图2所示,IBD组观察评分高于SO组及SLBZS组。SLBZS组观察评分明显低于IBD组。以平均值 ± 标准差(n = 8)表示。IBD组与SO组比较,*P < 0.05、**P < 0.01;SLBZS组与IBD组比较#P < 0.05、##P < 0.01。
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[43]
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Figure 2. Score of observation
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图2. 观察评分
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[45]
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如图3所示,IBD组大鼠结肠全长小于SO组,与IBD组相比,SLBZS组大鼠结肠长度增长。同时从肉眼观察看,SLBZS组大鼠结肠炎症及水肿程度较IBD组低。
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Figure 3. Colon length and morphology
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图3. 结肠长度及形态
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如图4所示,SO组各层结肠组织结构完整,黏膜微绒毛排列整齐,杯状细胞丰富,隐窝结构正常,结肠腺规则,无炎性细胞浸润。在IBD组中,出现了粘膜上皮细胞坏死,细胞排列紊乱,杯状细胞和隐窝减少以及炎性细胞浸润。SLBZS组结肠组织肠粘膜上皮、杯状细胞以及隐窝数量有所回升。
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[49]
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Figure 4. Pathological analysis of colon tissue
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图4. 结肠组织病理分析
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如图5所示,SO组大鼠SCFAs中乙酸、丙酸、丁酸含量显著高于IBD组,同时SLBZS组肠道中三种主要的SCFAs含量较IBD组均出现回升。以平均值 ± 标准差(n = 8)表示。IBD组与SO组比较,*P < 0.05、**P < 0.01;SLBZS组与IBD组比较#P < 0.05、##P < 0.01。
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[52]
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Figure 5. Measurement of SCFAs
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图5. 短链脂肪酸测定
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