[1]
|
Andrews, G. P., Qian, K., Jacobs, E., et al. (2023) High Drug Loading Nanosized Amorphous Solid Dispersion (NASD) with Enhanced in Vitro Solubility and Permeability: Benchmarking Conventional ASD. International Journal of Phar-maceutics, 632, Article ID: 122551. https://doi.org/10.1016/j.ijpharm.2022.122551
|
[2]
|
Tian, Z., Mai, Y., Meng, T., et al. (2021) Nanocrystals for Improving Oral Bioavailability of Drugs: Intestinal Transport Mechanisms and Influ-encing Factors. AAPS PharmSciTech, 22, Article No. 179.
https://doi.org/10.1208/s12249-021-02041-7
|
[3]
|
李嘉雯, 刘伟新, 王晶, 等. 新型药物递送系统在口服给药方面的应用前景[J]. 动物医学进展, 2023, 44(8): 121-126.
|
[4]
|
李亚平, 张志文, 王冠茹, 等. 提高难溶性药物口服生物利用度的制剂新技术[M]. 上海: 中国科学院上海药物研究所, 2021.
|
[5]
|
曹麒麟, 韩晓璐, 高静, 等. 提高难溶性药物生物利用度的研究进展[J]. 湖北科技学院学报(医学版), 2021, 35(4): 352-356.
|
[6]
|
Kotta, S., Khan, A.W., Pramod, K., et al. (2012) Exploring Oral Nanoemulsions for Bioavailability Enhancement of Poorly Water-Soluble Drugs. Expert Opinion on Drug Delivery, 9, 585-598.
https://doi.org/10.1517/17425247.2012.668523
|
[7]
|
范未伟. 胰岛素新型口服纳米载体的设计及其体内高效递送机制的研究[D]: [博士学位论文]. 北京: 中国科学院大学(中国科学院上海药物研究所), 2019.
|
[8]
|
Padhye, T., Maravajjala, K.S., Swetha, K.L., et al. (2021) A Comprehensive Review of the Strategies to Improve Oral Drug Ab-sorption with Special Emphasis on the Cellular and Molecular Mechanisms. Journal of Drug Delivery Science and Technology, 61, Article ID: 102178. https://doi.org/10.1016/j.jddst.2020.102178
|
[9]
|
Gaucher, G., Satturwar, P., Jones, M.C., et al. (2010) Polymeric Micelles for Oral Drug Delivery. European Journal of Pharmaceutics and Bio-pharmaceutics, 76, 147-158. https://doi.org/10.1016/j.ejpb.2010.06.007
|
[10]
|
Fine-Shamir, N., Beig, A., Miller, J.M., et al. (2020) The Solubility, Permeability and the Dose as Key Factors in Formulation Development for Oral Lipo-philic Drugs: Maximizing the Bioavailability of Carbamazepine with a Cosolvent-Based Formulation. International Journal of Pharmaceutics, 582, Article ID: 119307.
https://doi.org/10.1016/j.ijpharm.2020.119307
|
[11]
|
Dahan, A., Beig, A., Lindley, D., et al. (2016) The Solubili-ty-Permeability Interplay and Oral Drug Formulation Design: Two Heads Are Better than One. Advanced Drug Delivery Reviews, 101, 99-107.
https://doi.org/10.1016/j.addr.2016.04.018
|
[12]
|
Masaoka, Y., Tanaka, Y., Kataoka, M., et al. (2006) Site of Drug Absorption after Oral Administration: Assessment of Membrane Permeability and Luminal Concentration of Drugs in Each Segment of Gastrointestinal Tract. European Journal of Pharmaceutical Sciences, 29, 240-250. https://doi.org/10.1016/j.ejps.2006.06.004
|
[13]
|
Liu, Y., Yang, T., Wei, S., et al. (2018) Mucus Adhesion- and Penetration-Enhanced Liposomes for Paclitaxel Oral Delivery. International Journal of Pharmaceutics, 537, 245-256. https://doi.org/10.1016/j.ijpharm.2017.12.044
|
[14]
|
Enright, E.F., Griffin, B.T., Gahan, C.G.M., et al. (2018) Mi-crobiome-Mediated Bile Acid Modification: Role in Intestinal Drug Absorption and Metabolism. Pharmacological Re-search, 133, 170-186.
https://doi.org/10.1016/j.phrs.2018.04.009
|
[15]
|
Wahlström, A., Sayin, S.I., Marschall, H.U., et al. (2016) Intestinal Crosstalk Between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metabolism, 24, 41-50. https://doi.org/10.1016/j.cmet.2016.05.005
|
[16]
|
Pan, W., Xue, B., Yang, C., et al. (2018) Biopharmaceutical Char-acters and Bioavailability Improving Strategies of Ginsenosides. Fitoterapia, 129, 272-282. https://doi.org/10.1016/j.fitote.2018.06.001
|
[17]
|
Yu, M., Yang, Y., Zhu, C., et al. (2016) Advances in the Transep-ithelial Transport of Nanoparticles. Drug Discovery Today, 21, 1155-1161. https://doi.org/10.1016/j.drudis.2016.05.007
|
[18]
|
周晶. 调控肠道代谢提高药物口服生物利用度的制剂技术研究[D]: [博士学位论文]. 北京: 北京协和医学院, 2015.
|
[19]
|
Suzuki, K., Taniyama, K., Aoyama, T., et al. (2020) Evaluation of the Role of P-Glycoprotein (P-Gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-Gp Inhibitor, in Rats. European Journal of Drug Metabolism and Pharmacokinetics, 45, 385-392. https://doi.org/10.1007/s13318-019-00602-7
|
[20]
|
曹姗, 夏云, 曲虹, 等. 纳米技术提高难溶性药物口服给药生物利用度[J]. 吉林医学, 2020, 41(1): 206-208.
|
[21]
|
Chen, T., Li, Y., Wu, W., et al. (2016) Enhanced Dissolution, Oral Bioavailability and Brain Delivery by Formulation Schisantherin A into Nanocrystals. Nanomedicine: Nanotechnol-ogy, Biology and Medicine, 12, 503.
https://doi.org/10.1016/j.nano.2015.12.160
|
[22]
|
Bapat, P., Ghadi, R., Chaudhari, D., et al. (2019) Tocophersolan Stabilized Lipid Nanocapsules with High Drug Loading to Improve the Permeability and Oral Bioavailability of Curcu-min. International Journal of Pharmaceutics, 560, 219-227. https://doi.org/10.1016/j.ijpharm.2019.02.013
|
[23]
|
Yavarpour-Bali, H., Ghasemi-Kasman, M. and Pirzadeh, M. (2019) Curcumin-Loaded Nanoparticles: A Novel Therapeutic Strategy in Treatment of Central Nervous System Disor-ders. International Journal of Nanomedicine, 14, 4449-4460. https://doi.org/10.2147/IJN.S208332
|
[24]
|
Santos, A.C., Pereira, I., Pereira-Silva, M., et al. (2019) Nanotechnology-Based Formulations for Resveratrol Delivery: Effects on Resveratrol in Vivo Bioavailability and Bioactivity. Colloids and Surfaces B: Biointerfaces, 180, 127-140.
https://doi.org/10.1016/j.colsurfb.2019.04.030
|
[25]
|
Annaji, M., Poudel, I., Boddu, S.H.S., et al. (2021) Resvera-trol-Loaded Nanomedicines for Cancer Applications. Cancer Reports, 4, e1353. https://doi.org/10.1002/cnr2.1353
|
[26]
|
Baek, Y., Jeong, E.W. and Lee, H.G. (2023) Encapsulation of Resveratrol within Size-Controlled Nanoliposomes: Impact on Solubility, Stability, Cellular Permeability, and Oral Bioavailability. Colloids and Surfaces B: Biointerfaces, 224, Article ID: 113205. https://doi.org/10.1016/j.colsurfb.2023.113205
|
[27]
|
苏元元, 付宇, 李楠楠, 等. 三种达玛烷型皂苷的生物药剂学分类及吸收机制研究[J]. 中国现代中药, 2018, 20(9): 1150-1156.
|
[28]
|
Wang, Q., Wang, Y., Xie, Y., et al. (2021) Nonionic Surfactant Vesicles as a Novel Drug De-livery System for Increasing the Oral Bioavailability of Ginsenoside Rb1. Food Bioscience, 42, Article ID: 101064.
https://doi.org/10.1016/j.fbio.2021.101064
|
[29]
|
李楠楠. 萜类中药有效成分BCS分类及吸收机制研究[D]: [硕士学位论文]. 哈尔滨: 哈尔滨商业大学, 2019.
|
[30]
|
Wu, C., Li, B., Zhang, Y., et al. (2020) Intranasal Delivery of Paeoniflorin Nanocrystals for Brain Targeting. Asian Journal of Pharmaceutical Sciences, 15, 326-335. https://doi.org/10.1016/j.ajps.2019.11.002
|
[31]
|
Li, H., Cao, X., Liu, Y., et al. (2019) Establishment of Modified Biopharmaceutics Classification System Absorption Model for Oral Traditional Chinese Medicine (Sanye Tablet). Jour-nal of Ethnopharmacology, 244, Article ID: 112148.
https://doi.org/10.1016/j.jep.2019.112148
|
[32]
|
Bohley, M., Haunberger, A. and Goepferich, A.M. (2019) Intracel-lular Availability of Poorly Soluble Drugs from Lipid Nanocapsules. European Journal of Pharmaceutics and Biophar-maceutics, 139, 23-32.
https://doi.org/10.1016/j.ejpb.2019.03.007
|
[33]
|
Zhang, X., Su, J., Wang, X., et al. (2022) Preparation and Proper-ties of Cyclodextrin Inclusion Complexes of Hyperoside. Molecules, 27, Article 2761. https://doi.org/10.3390/molecules27092761
|
[34]
|
Wang, Y., Tan, X., Fan, X., et al. (2021) Current Strategies for Oral Delivery of BCS IV Drug Nanocrystals: Challenges, Solutions and Future Trends. Expert Opinion on Drug Deliv-ery, 18, 1211-1228.
https://doi.org/10.1080/17425247.2021.1903428
|
[35]
|
Fu, W., Liang, Y., Xie, Z., et al. (2021) Preparation and Evaluation of Lecithin/Zein Hybrid Nanoparticles for the Oral Delivery of Panax Notoginseng Saponins. European Journal of Pharmaceutical Sciences, 164, Article ID: 105882.
https://doi.org/10.1016/j.ejps.2021.105882
|
[36]
|
Zare-Zardini, H., Alemi, A., Taheri-Kafrani, A., et al. (2020) As-sessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in Vitro Study. Drug Design, Development and Therapy, 14, 3315-3324. https://doi.org/10.2147/DDDT.S261027
|
[37]
|
Cheng, M., Yuan, F., Liu, J., et al. (2020) Fabrication of Fine Puerarin Nanocrystals by Box-Behnken Design to Enhance Intestinal Absorption. AAPS PharmSciTech, 21, 90-101. https://doi.org/10.1208/s12249-019-1616-4
|
[38]
|
Huang, T., Liu, Y. and Zhang, C. (2019) Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review. European Journal of Drug Metabolism and Pharmacokinetics, 44, 159-168.
https://doi.org/10.1007/s13318-018-0509-3
|
[39]
|
Xu, W., Niu, Y., Ai, X., et al. (2022) Liver-Targeted Nanoparti-cles Facilitate the Bioavailability and Anti-HBV Efficacy of Baicalin in Vitro and in Vivo. Biomedicines, 10, 900-915. https://doi.org/10.3390/biomedicines10040900
|
[40]
|
周剑雄, 吴送姑, 龚俊波, 等. 小檗碱的药理活性以及提升其口服生物利用度的策略[J]. 药学学报, 2022, 57(5): 1263-1272.
|
[41]
|
容爽. 小檗碱及其纳米制剂的生物活性研究[D] : [硕士学位论文]. 重庆: 西南大学, 2022.
|
[42]
|
蒋蕾, 孙旭, 刘肖莹, 等. 小檗碱纳米制剂的制备及表征研究[J]. 中医药信息, 2022, 39(3): 16-19.
|
[43]
|
Alsabeelah, N. and Kumar, V. (2022) Quality by Design-Based Optimiza-tion of Formulation and Process Parameters for Berberine Nanosuspension for Enhancing Its Dissolution Rate, Bioa-vailability, and Cardioprotective Activity. Journal of Food Biochemistry, 46, e14361. https://doi.org/10.1111/jfbc.14361
|
[44]
|
Li, Z., Liu, Y., Wang, J., et al. (2022) Baicalin-Berberine Complex Nano-crystals Orally Promote the Co-Absorption of Two Components. Drug Delivery and Translational Research, 12, 3017-3028.
https://doi.org/10.1007/s13346-022-01167-w
|
[45]
|
孙嘉慧, 唐海, 杨美青, 等. 固体分散体技术提高难溶性药物溶解度研究进展[J]. 化工与医药工程, 2021, 42(5): 38-43.
|
[46]
|
Al-Kassas, R., Bansal, M. and Shaw, J. (2017) Nanosizing Techniques for Improving Bioavailability of Drugs. Journal of Controlled Release, 260, 202-212. https://doi.org/10.1016/j.jconrel.2017.06.003
|
[47]
|
朱卫丰, 丁权, 李文栋, 等. 口服纳米颗粒在胃肠道中的跨膜转运研究进展[J]. 中国实验方剂学杂志, 2021, 27(9): 215-223.
|
[48]
|
张军. 基于微流控技术制备姜黄素纳米晶及其口服生物利用度研究[D] : [硕士学位论文]. 大理: 大理大学, 2022.
|
[49]
|
Mcclements, D.J. (2010) Emulsion Design to Improve the Delivery of Functional Lipophilic Components. Annual Review of Food Science and Technology, 1, 241-269. https://doi.org/10.1146/annurev.food.080708.100722
|
[50]
|
Chen, B.H. and Stephen Inbaraj, B. (2019) Nanoemulsion and Nanoliposome Based Strategies for Improving Anthocyanin Stability and Bioavailability. Nutrients, 11, Article 1052. https://doi.org/10.3390/nu11051052
|
[51]
|
Chen, T.E., Tu, L., Wang, G., et al. (2020) Mul-ti-Functional Chitosan Polymeric Micelles as Oral Paclitaxel Delivery Systems for Enhanced Bioavailability and An-ti-Tumor Efficacy. International Journal of Pharmaceutics, 578, Article ID: 119105. https://doi.org/10.1016/j.ijpharm.2020.119105
|
[52]
|
Teixeira, M.C., Carbone, C. and Souto, E.B. (2017) Beyond Liposomes: Recent Advances on Lipid Based Nanostructures for Poorly Soluble/Poorly Permeable Drug Delivery. Pro-gress in Lipid Research, 68, 1-11.
https://doi.org/10.1016/j.plipres.2017.07.001
|
[53]
|
Talegaonkar, S. and Bhattacharyya, A. (2019) Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability. AAPS PharmSciTech, 20, 121-135.
https://doi.org/10.1208/s12249-019-1337-8
|
[54]
|
Nguyen, V.H., Thuy, V.N., Van, T.V., et al. (2022) Nanostruc-tured Lipid Carriers and Their Potential Applications for Versatile Drug Delivery via Oral Administration. OpenNano, 8, Article ID: 100064.
https://doi.org/10.1016/j.onano.2022.100064
|
[55]
|
Ashour, A.A., Ramadan, A.A., Abdelmonsif, D.A., et al. (2020) Enhanced Oral Bioavailability of Tanshinone IIA Using Lipid Nanocapsules: Formulation, In-Vitro Appraisal and Phar-macokinetics. International Journal of Pharmaceutics, 586, Article ID: 119598. https://doi.org/10.1016/j.ijpharm.2020.119598
|
[56]
|
Mittal, P. and Hazari, P.P. (2023) 14—Nanotubes-Based Brain Targeted Drug Delivery System: A Step toward Improving Bioavailability and Drug Enhancement at the Target Site. In: Sharma, N. and Butola, B.S., Eds., Fiber and Textile Engineering in Drug Delivery Systems, Woodhead Publishing, Cambridge, 417-441.
https://doi.org/10.1016/B978-0-323-96117-2.00009-1
|
[57]
|
Zhou, W., Li, B., Min, R., et al. (2023) Mu-cus-Penetrating Dendritic Mesoporous Silica Nanoparticle Loading Drug Nanocrystal Clusters to Enhance Permeation and Intestinal Absorption. Biomaterials Science, 11, 1013-1030.
https://doi.org/10.1039/D2BM01404A
|
[58]
|
Tollemeto, M., Huang, Z., Christensen, J.B., et al. (2023) Mucoad-hesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals. ACS Applied Materials & Interfaces, 15, 8798-8810. https://doi.org/10.1021/acsami.2c16502
|
[59]
|
Bazzo, G.C., Pezzini, B.R. and Stulzer, H.K. (2020) Eutectic Mixtures as an Approach to Enhance Solubility, Dissolution Rate and Oral Bioavailability of Poorly Water-Soluble Drugs. Inter-national Journal of Pharmaceutics, 588, Article ID: 119741. https://doi.org/10.1016/j.ijpharm.2020.119741
|
[60]
|
Tran, P., Pyo, Y.C., Kim, D.H., et al. (2019) Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs. Pharmaceutics, 11, Article 132. https://doi.org/10.3390/pharmaceutics11030132
|
[61]
|
Alshehri, S., Imam, S.S., Hussain, A., et al. (2020) Potential of Solid Dispersions to Enhance Solubility, Bioavailability, and Therapeutic Efficacy of Poorly Water-Soluble Drugs: Newer Formulation Techniques, Current Marketed Scenario and Patents. Drug Delivery, 27, 1625-1643. https://doi.org/10.1080/10717544.2020.1846638
|