[1]
|
Villanueva, A. (2019) Hepatocellular Carcinoma. The New England Journal of Medicine, 380, 1450-1462.
https://doi.org/10.1056/NEJMra1713263
|
[2]
|
中华人民共和国国家卫生健康委员会. 原发性肝癌诊疗指南(2022年版) [J]. 临床肝胆病杂志, 2022, 38(5): 1027-1029.
|
[3]
|
Vogel, A., Meyer, T., Sapisochin, G., et al. (2022) Hepatocellular Carcinoma. The Lancet, 400, 1345-1362.
https://doi.org/10.1016/S0140-6736(22)01200-4
|
[4]
|
Wu, J., Qiao, S., Xiang, Y., et al. (2021) Endoplasmic Reticulum Stress: Multiple Regulatory Roles in Hepatocellular Carcinoma. Biomedicine & Pharmacotherapy, 142, Article ID: 112005. https://doi.org/10.1016/j.biopha.2021.112005
|
[5]
|
Marciniak, S.J., Chambers, J.E. and Ron, D. (2022) Pharmacological Targeting of Endoplasmic Reticulum Stress in Disease. Nature Reviews Drug Discovery, 21, 115-140. https://doi.org/10.1038/s41573-021-00320-3
|
[6]
|
Pavlović, N. and Heindryckx, F. (2022) Targeting ER Stress in the Hepatic Tumor Microenvironment. FEBS Journal, 289, 7163-7176. https://doi.org/10.1111/febs.16145
|
[7]
|
Oakes, S.A. and Papa, F.R. (2015) The Role of Endoplasmic Reticulum Stress in Human Pathology. Annual Review of Pathology, 10, 173-194. https://doi.org/10.1146/annurev-pathol-012513-104649
|
[8]
|
Oakes, S.A. (2020) Endoplasmic Reticulum Stress Signaling in Cancer Cells. The American Journal of Pathology, 190, 934-946. https://doi.org/10.1016/j.ajpath.2020.01.010
|
[9]
|
Shore, G.C., Papa, F.R. and Oakes, S.A. (2011) Signaling Cell Death from the Endoplasmic Reticulum Stress Response. Current Opinion in Cell Biology, 23, 143-149. https://doi.org/10.1016/j.ceb.2010.11.003
|
[10]
|
Bommiasamy, H., Back, S.H., Fagone, P., et al. (2009) ATF6alpha Induces XBP1-Independent Expansion of the Endoplasmic Reticulum. Journal of Cell Science, 122, 1626-1636. https://doi.org/10.1242/jcs.045625
|
[11]
|
Khaled, J., Kopsida, M., Lennernäs, H., et al. (2022) Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma. Cells, 11, 632. https://doi.org/10.3390/cells11040632
|
[12]
|
Hong, F., Lin, C.Y., Yan, J., et al. (2022) Canopy Homolog 2 Contributes to Liver Oncogenesis by Promoting Unfolded Protein Response-Dependent Destabilization of Tumor Protein P53. Hepatology, 76, 1587-1601.
https://doi.org/10.1002/hep.32318
|
[13]
|
Qi, Q., Niture, S., Gadi, S., et al. (2023) Per- and Polyfluoroalkyl Substances Activate UPR Pathway, Induce Steatosis and Fibrosis in Liver Cells. Environmental Toxicology, 38, 225-242. https://doi.org/10.1002/tox.23680
|
[14]
|
Song, J., Ding, W., Liu, B., et al. (2020) Anticancer Effect of Caudatin in Diethylnitrosamine‑Induced Hepatocarcinogenesis in Rats. Molecular Medicine Reports, 22, 697-706. https://doi.org/10.3892/mmr.2020.11135
|
[15]
|
Lu, Y., Wang, L.R., Lee, J., et al. (2022) The Unfolded Protein Response to PI*Z Alpha-1 Antitrypsin in Human Hepatocellular and Murine Models. Hepatology Communications, 6, 2354-2367. https://doi.org/10.1002/hep4.1997
|
[16]
|
Aran, G., Sanjurjo, L., Bárcena, C., et al. (2018) CD5L Is Upregulated in Hepatocellular Carcinoma and Promotes Liver Cancer Cell Proliferation and Antiapoptotic Responses by Binding to HSPA5 (GRP78). FASEB Journal, 32, 3878-3891. https://doi.org/10.1096/fj.201700941RR
|
[17]
|
Papaioannou, A., Higa, A., Jégou, G., et al. (2018) Alterations of EDEM1 Functions Enhance ATF6 Pro-Survival Signaling. FEBS Journal, 285, 4146-4164. https://doi.org/10.1111/febs.14669
|
[18]
|
Barnault, R., Lahlali, T., Plissonnier, M.-L., et al. (2018) Hepatocellular Carcinoma-Associated Depletion of the Netrin-1 Receptor Uncoordinated Phenotype-5A (UNC5A) Skews the Hepatic Unfolded Protein Response towards Prosurvival Outcomes. Biochemical and Biophysical Research Communications, 495, 2425-2431.
https://doi.org/10.1016/j.bbrc.2017.12.129
|
[19]
|
Wei, C., Yang, X., Liu, N., et al. (2019) Tumor Microenvironment Regulation by the Endoplasmic Reticulum Stress Transmission Mediator Golgi Protein 73 in Mice. Hepatology, 70, 851-870. https://doi.org/10.1002/hep.30549
|
[20]
|
Pavlović, N., Kopsida, M., Gerwins, P., et al. (2020) Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. International Journal of Molecular Sciences, 21, 8177.
https://doi.org/10.3390/ijms21218177
|
[21]
|
Li, Y., Xia, Y., Cheng, X., et al. (2019) Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B. Viruses, 11, 386. https://doi.org/10.3390/v11040386
|
[22]
|
Liang, Y.-J., Teng, W., Chen, C.-L., et al. (2021) Clinical Implications of HBV PreS/S Mutations and the Effects of PreS2 Deletion on Mitochondria, Liver Fibrosis, and Cancer Development. Hepatology, 74, 641-655.
https://doi.org/10.1002/hep.31789
|
[23]
|
Wu, S.-X., Ye, S.-S., Hong, Y.-X., et al. (2022) Hepatitis B Virus Small Envelope Protein Promotes Hepatocellular Carcinoma Angiogenesis via Endoplasmic Reticulum Stress Signaling to Upregulate the Expression of Vascular Endothelial Growth Factor A. Journal of Virology, 96, e0197521. https://doi.org/10.1128/jvi.01975-21
|
[24]
|
Armentano, M.F., Caterino, M., Miglionico, R., et al. (2018) New Insights on the Functional Role of URG7 in the Cellular Response to ER Stress. Biology of the Cell, 110, 147-158. https://doi.org/10.1111/boc.201800004
|
[25]
|
Aydin, Y., Kurt, R., Song, K., et al. (2019) Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression. Cancers (Basel), 11, 1407.
https://doi.org/10.3390/cancers11101407
|
[26]
|
Zhou, B., Lu, Q., Liu, J., et al. (2019) Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway. International Journal of Biological Sciences, 15, 1905-1920.
https://doi.org/10.7150/ijbs.32550
|
[27]
|
Lin, J.-C., Yang, P.-M. and Liu, T.-P. (2021) PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences, 22, 5848.
https://doi.org/10.3390/ijms22115848
|
[28]
|
Guo, B., Xu, X., Shao, M., et al. (2022) UDP-Glucose 6-Dehydrogenase Lessens Sorafenib Sensitivity via Modulating Unfolded Protein Response. Biochemical and Biophysical Research Communications, 613, 207-213.
https://doi.org/10.1016/j.bbrc.2022.05.048
|
[29]
|
Chiu, C.-C., Chen, Y.-C., Bow, Y.-D., et al. (2022) diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C2-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation. Cancers (Basel), 14, 2528. https://doi.org/10.3390/cancers14102528
|
[30]
|
Liu, Y., Tao, S., Liao, L., et al. (2020) TRIM25 Promotes the Cell Survival and Growth of Hepatocellular Carcinoma through Targeting Keap1-Nrf2 Pathway. Nature Communications, 11, 348.
https://doi.org/10.1038/s41467-019-14190-2
|
[31]
|
Liu, H., Xie, S., Fang, F., et al. (2020) SHQ1 Is an ER Stress Response Gene That Facilitates Chemotherapeutics-Induced Apoptosis via Sensitizing ER-Stress Response. Cell Death & Disease, 11, 445.
https://doi.org/10.1038/s41419-020-2656-0
|
[32]
|
Munakarmi, S., Shrestha, J., Shin, H.-B., et al. (2021) 3,3’-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis. Cells, 10, 1178.
https://doi.org/10.3390/cells10051178
|
[33]
|
Rinaldi, R., Miglionico, R., Nigro, I., et al. (2021) Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2. Cells, 10, 3052.
https://doi.org/10.3390/cells10113052
|
[34]
|
Li, X., Chen, Q., Liu, J., et al. (2022) Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma. Cells, 11, 3870.
https://doi.org/10.3390/cells11233870
|
[35]
|
Choi, C., Cho, Y., Son, A., et al. (2020) Therapeutic Potential of (-)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge Agelas sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models. Marine Drugs, 18, 500.
https://doi.org/10.3390/md18100500
|
[36]
|
Ding, Y., Chen, X., Wang, B., et al. (2018) Deubiquitinase Inhibitor b-AP15 Activates Endoplasmic Reticulum (ER) Stress and Inhibits Wnt/Notch1 Signaling Pathway Leading to the Reduction of Cell Survival in Hepatocellular Carcinoma Cells. European Journal of Pharmacology, 825, 10-18. https://doi.org/10.1016/j.ejphar.2018.02.020
|
[37]
|
Shi, T.-L., Zhang, L., Cheng, Q.-Y., et al. (2019) Xanthatin Induces Apoptosis by Activating Endoplasmic Reticulum Stress in Hepatoma Cells. European Journal of Pharmacology, 843, 1-11. https://doi.org/10.1016/j.ejphar.2018.10.041
|
[38]
|
Kim, S.Y., Hwang, S., Lee, B.R., et al. (2022) Inhibition of Histone Demethylase KDM4 by ML324 Induces Apoptosis through the Unfolded Protein Response and Bim Upregulation in Hepatocellular Carcinoma Cells. Chemico-Biological Interactions, 353, Article ID: 109806. https://doi.org/10.1016/j.cbi.2022.109806
|
[39]
|
Hwang, S., Kim, S., Kim, K., et al. (2020) Euchromatin Histone Methyltransferase II (EHMT2) Regulates the Expression of Ras-Related GTP Binding C (RRAGC) Protein. BMB Reports, 53, 576-581.
https://doi.org/10.5483/BMBRep.2020.53.11.055
|
[40]
|
Pomlok, K., Pata, S., Kulaphisit, M., et al. (2022) An IgM Monoclonal Antibody against Domain 1 of CD147 Induces Non-Canonical RIPK-Independent Necroptosis in a Cell Type Specific Manner in Hepatocellular Carcinoma Cells. BBA Molecular Cell Research, 1869, Article ID: 119295. https://doi.org/10.1016/j.bbamcr.2022.119295
|
[41]
|
Chen, J., Zhang, Z.-Q., Song, J., et al. (2018) 18β-Glycyrrhetinic-Acid-Mediated Unfolded Protein Response Induces Autophagy and Apoptosis in Hepatocellular Carcinoma. Scientific Reports, 8, 9365.
https://doi.org/10.1038/s41598-018-27142-5
|
[42]
|
Pibiri, M., Sulas, P., Camboni, T., et al. (2020) α-Lipoic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Hepatoma Cells. Scientific Reports, 10, 7139. https://doi.org/10.1038/s41598-020-64004-5
|
[43]
|
Al-Hrout, A.A., Chaiboonchoe, A., Khraiwesh, B., et al. (2018) Safranal Induces DNA Double-Strand Breakage and ER-Stress-Mediated Cell Death in Hepatocellular Carcinoma Cells. Scientific Reports, 8, 16951.
https://doi.org/10.1038/s41598-018-34855-0
|
[44]
|
Zheng, X., Liu, B., Liu, X., et al. (2022) PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis. Journal of Cancer, 13, 669-680.
https://doi.org/10.7150/jca.61622
|
[45]
|
Forno, F., Maatuf, Y., Boukeileh, S., et al. (2020) Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells. Journal of Pharmacology and Experimental Therapeutics, 374, 452-461.
https://doi.org/10.1124/jpet.119.264481
|
[46]
|
Goyal, H., Sharma, R., Lamba, D., et al. (2023) Folic Acid Depletion along with Inhibition of the PERK Arm of Endoplasmic Reticulum Stress Pathway Promotes a Less Aggressive Phenotype of Hepatocellular Carcinoma Cells. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-022-04651-6
|