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Vol. 2 No. 1 (February 2014)
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尿素通道蛋白B的转运特性
Transport Characteristics of Urea Transporter-B
DOI:
10.12677/JPS.2014.21001
,
PDF
,
HTML
,
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被引量
下载: 3,415
浏览: 12,926
国家自然科学基金支持
作者:
钟丹丹
,
杨宝学
:天然药物及仿生药物国家重点实验室,北京大学基础医学院药理学系,北京
关键词:
尿素通道蛋白B
;
尿素
;
尿素类似物
;
NH3
;
水
;
UT-B; Urea; Urea Analogues; Ammonia; Water
摘要:
尿素通道蛋白
B
(
urea transporters B, UT-B
)
主要表达在红细胞和一些上皮及内皮细胞膜,介导尿素的跨膜转运。近年来研究发现
UT-B
亦参与其他物质的转运,如水、
NH
3
和尿素类似物等,提示
UT-B
还可以作为水和气体通道。本文主要阐述
UT-B
对这些物质的转运特性,并探究其可能的
生理学意义
。
Urea transporter UT-B is highly expressed in the membrane of erythrocytes and some epithelial and endothelial cells, in which UT-B facilitates urea transport. Recently, studies find that water, ammonia and urea analogues can also be transported by UT-B. This review mainly focuses on the transport characteristics of UT-B, and the possible physiological significance will be discussed as well.
文章引用:
钟丹丹, 杨宝学. 尿素通道蛋白B的转运特性[J]. 生理学研究, 2014, 2(1): 1-4.
http://dx.doi.org/10.12677/JPS.2014.21001
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