内含子的进化及其转录调控功能的统计分析
The Evolution and Regulatory Function of Transcription in Intron
DOI: 10.12677/HJCB.2013.34004, PDF, HTML,  被引量 下载: 3,471  浏览: 13,108 
作者: 胡 俊, 杨建红：云南农业大学基础与信息工程学院，昆明
关键词: 内含子；进化；转录调控；统计分析；转录协同作用；Intron; Evolution; Transcriptional Regulatory; Statistical Analysis; Transcriptional Synergy
摘要: 关于内含子的起源和进化有内含子早现(introns-early)和内含子晚现(introns-late)两种假说。内含子早现理论认为内含子是基因原来就有的结构；内含子晚现理论认为内含子是在进化过程中插入基因中的。除了提供多种剪切方式外，内含子中还有多种顺式作用元件参与转录调控，对酵母基因内含子转录调控功能的统计分析显示酵母基因上游与内含子之间可能存在的一些转录协同作用模式。
Abstract: There are two opposing theories about intron originated and evolved. The introns-early theory believed that introns had already existed at the beginning of life. However, the introns-late theory believed that the introns were inserted into genes during the course of evolution. Some cis-elements in introns play a key role in transcriptional regulatory. The statistical analysis of transcriptional regulatory function showed that there are some potential patterns of transcriptional synergy between 5’-UTR and introns.
文章引用：胡俊, 杨建红. 内含子的进化及其转录调控功能的统计分析[J]. 计算生物学, 2013, 3(4): 21-23. http://dx.doi.org/10.12677/HJCB.2013.34004

参考文献

[1] 罗静初 (2002) 生物信息学概论. 北京大学出版社, 北京, 255.
[2] 诸葛健, 王正祥 (2003) 现代英汉生物工程词典. 科学出版社, 北京.
[3] 袁建刚, 周严, 强伯勤, 等, 译 (2002) 基因组. 科学出版社, 北京, 238.
[4] Gilbert, W. (1978) Why genes in pieces? Nature, 271, 501.
[5] Darnell, J.E. and Doolittle, W.F. (1986) Speculations on the early course of evolution. Proceedings of the National Academy of Sciences USA, 83, 1271-1275.
[6] Cavalier-Smith, T. (1991) Intron phylogeny: A new hypothesis. Trends in Genetics, 7, 145-148.
[7] Rzhetsky, A., Ayala, F.J., Hsu, L.C., et al. (1997) Exon/intron structure of aldehyde dehydrogznase genes supports the “intronslate” theory. Proceedings of the National Academy of Sciences USA, 94, 6820-6825.
[8] 吴加金, 刘涛, 贺福初, 吴晓霞 (1998) 动物肌动蛋白基因中内含子的来源及存在意义的探讨. 遗传学报, 5, 409-415.
[9] 沈羽琲, 方德福 (1997) 真核基因表达调控. 高等教育出版社, 施普林格出版社, 北京, 39-47.
[10] 刘次全, 白春礼, 张静 (1997) 结构分子生物学. 高等教育出版社, 北京, 159-163.
[11] Katharina, H.S., Cox, T.C. and May, B.K. (1998) Identification and characterization of a conserved erythroid-specific enhancerlocated in intron 8 of the Human 5-Aminolevulinate Synthase 2 Gene. The Journal of Biological Chemistry, 273, 16798-16809.
[12] Bhattachcryyz, N. and Banerjee, D. (1999) Transcriptional regulatory sequences within the first intron of the chicken apolipoprotein AI(apoAI) gene. Gene, 234, 371-380.
[13] Brinste, R.L., Allen, J.M., Bbehringer, R.R., et al. (1988) Introns increase transcriptional efficiency in transgenic mice. Proceedings of the National Academy of Sciences USA, 85, 836-840.
[14] Clement, J.Q. and Wilkinson, M.F. (2000) Rapid induction of nuclear transcripts and inhibition of intron decay in response to the polymerase II inhibitor DRB. Journal of Molecular Biology, 299, 1179-1191.
[15] 张静, 石秀凡 (2003) 酵母基因中转录正调控内含子序列特征的统计分析. 生物化学与生物理进展, 2, 231-238.
[16] Zhang, J., Hu, J., Shi, X.-F., Cao, H. and Liu, W.-B. (2003) Detection of potential positive regulatory motifs of transcription in yeast introns by comparative analysis of oligonucleotide frequencies. Computational Biology and Chemistry, 27, 497-506．
[17] 张静, 石秀凡, 杨恒芬 (2003) 酵母内含子在基因序列中的分布对基因转录效率的影响. 生物化学与生物物理进展, 6, 945-949．
[18] Carey, M. and Smale, S.T. (2002) Transcriptional regulation in eukaryotes concepts strategies and techniques. Tsinghua University Press, Beijing.
[19] 薛文, 王进, 黄启来, 郑伟娟, 华子春 (2002) 真核基因转录激活的多位点协同调控. 生物化学与生物物理进展, 4, 510- 513.
[20] 张昆林, 张静, 罗静初 (2005) 酵母基因上游与内含子可能存在的转录协同作用. 生物化学与生物物理进展, 10, 953- 958.

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