[1]
|
Luo, C., Lancaster, M.A., Castanon, R., et al. (2016) Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain. Cell Reports, 17, 3369-3384. https://doi.org/10.1016/j.celrep.2016.12.001
|
[2]
|
Camp, J.G., Badsha, F., Florio, M., et al. (2016) Human Cerebral Organoids Recapitulate Gene Expression Programs of Fetal Neocortex Development. Proceedings of the National Academy of Sciences, 112, 15672-15677.
https://doi.org/10.1073/pnas.1520760112
|
[3]
|
Gordon, A., Yoon, S.J., Tran, S.S., et al. (2021) Long-Term Mat-uration of Human Cortical Organoids Matches Key Early Postnatal Transitions. Nature Neuroscience, 24, 331-342. https://doi.org/10.1038/s41593-021-00802-y
|
[4]
|
Zhang, W., Jiang, J., Xu, Z., et al. (2022) Microglia-Containing Human Brain Organoids for the Study of Brain Development and Pathology. Molecular Psychiatry, 28, 96-107. https://doi.org/10.1038/s41380-022-01892-1
|
[5]
|
Edri, R., Yaffe, Y., Ziller, M.J., et al. (2015) Analysing Human Neural Stem Cell Ontogeny by Consecutive Isolation of Notch Active Neural Progenitors. Nature Communications, 6, Article No. 6500.
https://doi.org/10.1038/ncomms7500
|
[6]
|
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., et al. (2008) Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals. Cell Stem Cell, 3, 519-532.
https://doi.org/10.1016/j.stem.2008.09.002
|
[7]
|
Eiraku, M., Takata, N., Ishibashi, H., et al. (2011) Self-Organizing Optic-Cup Morphogenesis in Three-Dimensional Culture. Nature, 472, 51-56. https://doi.org/10.1038/nature09941
|
[8]
|
Lancaster, M.A., Renner, M., Martin, C.A., et al. (2013) Cerebral Organoids Model Human Brain Development and Microcephaly. Nature, 501, 373-379. https://doi.org/10.1038/nature12517
|
[9]
|
Krefft, O., Jabali, A., Iefremova, V., et al. (2018) Generation of Stand-ardized and Reproducible Forebrain-Type Cerebral Organoids from Human Induced Pluripotent Stem Cells. Journal of Visualized Experiments, No. 131, 56768.
https://doi.org/10.3791/56768
|
[10]
|
Xiang, Y., Tanaka, Y., Patterson, B., et al. (2017) Fusion of Regionally Spec-ified HPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell, 21, 383-398.E7.
https://doi.org/10.1016/j.stem.2017.07.007
|
[11]
|
Sakaguchi, H., Kadoshima, T., Soen, M., et al. (2015) Generation of Functional Hippocampal Neurons from Self-Organizing Human Embryonic Stem Cell-Derived Dorsomedial Telencephalic Tissue. Nature Communications, 6, Article No. 8896.
https://doi.org/10.1038/ncomms9896
|
[12]
|
Qian, X., Nguyen, H.N., Song, M.M., et al. (2016) Brain-Region-Specific Organoids Using Mini-Bioreactors for Modeling ZIKV Exposure. Cell, 165, 1238-1254. https://doi.org/10.1016/j.cell.2016.04.032
|
[13]
|
Kawada, J., Kaneda, S., Kirihara, T., et al. (2017) Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons. Stem Cell Reports, 9, 1441-1449. https://doi.org/10.1016/j.stemcr.2017.09.021
|
[14]
|
Pham, M.T., Pollock, K.M., Rose, M.D., et al. (2018) Genera-tion of Human Vascularized Brain Organoids. NeuroReport, 29, 588-593. https://doi.org/10.1097/WNR.0000000000001014
|
[15]
|
Shi, Y., Sun, L., Wang, M., et al. (2020) Vascularized Human Cortical Organoids (VOrganoids) Model Cortical Development in Vivo. PLOS Biology, 18, e3000705. https://doi.org/10.1371/journal.pbio.3000705
|
[16]
|
Kook, M.G., Lee, S.E., Shin, N., et al. (2022) Generation of Cortical Brain Organoid with Vascularization by Assembling with Vascular Spheroid. International Journal of Stem Cells, 15, 85-94. https://doi.org/10.15283/ijsc21157
|
[17]
|
Li, R., Sun, L., Fang, A., et al. (2017) Recapitulating Cortical Development with Organoid Culture in Vitro and Modeling Abnormal Spindle-Like (ASPM Related Primary) Microcephaly Disease. Protein & Cell, 8, 823-833.
https://doi.org/10.1007/s13238-017-0479-2
|
[18]
|
Mellios, N., Feldman, D.A., Sheridan, S.D., et al. (2017) MeCP2-Regulated MiRNAs Control Early Human Neurogenesis through Differential Effects on ERK and AKT Sig-naling. Molecular Psychiatry, 23, 1051-1065.
https://doi.org/10.1038/mp.2017.86
|
[19]
|
Stachowiak, E.K., Benson, C.A., Narla, S.T., et al. (2017) Cerebral Organoids Reveal Early Cortical Maldevelopment in Schizophrenia—Computational Anatomy and Genomics, Role of FGFR1. Translational Psychiatry, 7, Article No. 6.
https://doi.org/10.1038/s41398-017-0054-x
|
[20]
|
Johnstone, M., Vasistha, N.A., Barbu, M.C., et al. (2018) Re-versal of Proliferation Deficits Caused by Chromosome 16p13.11 Microduplication through Targeting NFκB Signaling: An Integrated Study of Patient-Derived Neuronal Precursor Cells, Cerebral Organoids and in Vivo Brain Imaging. Mo-lecular Psychiatry, 24, 294-311.
https://doi.org/10.1038/s41380-018-0292-1
|
[21]
|
Li, Y., Muffat, J., Omer, A., et al. (2017) Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell, 20, 385-396.E3. https://doi.org/10.1016/j.stem.2016.11.017
|
[22]
|
Qian, X., Nguyen, H.N., Jacob, F., et al. (2017) Using Brain Organoids to Understand Zika Virus-Induced Microcephaly. Development, 144, 952-957. https://doi.org/10.1242/dev.140707
|
[23]
|
Ma, C., Seong, H., Li, X., et al. (2022) Human Brain Organoid: A Ver-satile Tool for Modeling Neurodegeneration Diseases and for Drug Screening. Stem Cells International, 2022, Article ID: 2150680.
https://doi.org/10.1155/2022/2150680
|
[24]
|
Li, Y., Zeng, P.M., Wu, J., et al. (2023) Advances and Applications of Brain Organoids. Neuroscience Bulletin, 39, 1703-1716. https://doi.org/10.1007/s12264-023-01065-2
|
[25]
|
Benito-Kwiecinski, S. and Lancaster, M.A. (2020) Brain Organoids: Human Neurodevelopment in a Dish. Cold Spring Harbor Perspectives in Biology, 12, a035709. https://doi.org/10.1101/cshperspect.a035709
|
[26]
|
Grenier, K., Kao, J. and Diamandis, P. (2019) Three-Dimensional Modeling of Human Neurodegeneration: Brain Organoids Coming of Age. Molecular Psychiatry, 25, 254-274. https://doi.org/10.1038/s41380-019-0500-7
|
[27]
|
Cakir, B., Xiang, Y., Tanaka, Y., et al. (2019) Engineering of Human Brain Organoids with a Functional Vascular-Like System. Nature Methods, 16, 1169-1175. https://doi.org/10.1038/s41592-019-0586-5
|
[28]
|
Kim, J.Y., Mo, H., Kim, J., et al. (2022) Mitigating Effect of Es-trogen in Alzheimer’s Disease-Mimicking Cerebral Organoid. Frontiers in Neuroscience, 16, Article ID: 816174. https://doi.org/10.3389/fnins.2022.816174
|
[29]
|
Gonzalez, C., Armijo, E., Bravo-Alegria, J., et al. (2018) Modeling Amyloid Beta and Tau Pathology in Human Cerebral Organoids. Molecular Psychiatry, 23, 2363-2374. https://doi.org/10.1038/s41380-018-0229-8
|
[30]
|
Pavoni, S., Jarray, R., Nassor, F., et al. (2018) Small-Molecule Induction of Aβ-42 Peptide Production in Human Cerebral Organoids to Model Alzheimer’s Disease Associated Phe-notypes. PLOS ONE, 13, e0209150.
https://doi.org/10.1371/journal.pone.0209150
|
[31]
|
Park, J., Lee, B.K., Jeong, G.S., et al. (2015) Three-Dimensional Brain-on-a-Chip with an Interstitial Level of Flow and Its Application as an in Vitro Model of Alzheimer’s Disease. Lab on a Chip, 15, 141-150.
https://doi.org/10.1039/C4LC00962B
|
[32]
|
Penney, J., Seo, J., Kritskiy, O., et al. (2017) Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects. The Journal of Neu-roscience, 37, 8655-8666.
https://doi.org/10.1523/JNEUROSCI.0591-17.2017
|
[33]
|
Raja, W.K., Mungenast, A.E., Lin, Y.T., et al. (2016) Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes. PLOS ONE, 11, e0161969.
https://doi.org/10.1371/journal.pone.0161969
|
[34]
|
Choi, S.H., Kim, Y.H., Hebisch, M., et al. (2014) A Three-Dimensional Human Neural Cell Culture Model of Alzheimer’s Disease. Nature, 515, 274-278. https://doi.org/10.1038/nature13800
|
[35]
|
Yin, J. and Van Dongen, A.M. (2021) Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease. ACS Biomaterials Science & Engineering, 7, 254-264.
https://doi.org/10.1021/acsbiomaterials.0c01583
|
[36]
|
Chen, X., Sun, G., Tian, E., et al. (2021) Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure. Advanced Science, 8, Article ID: 2101462. https://doi.org/10.1002/advs.202101462
|
[37]
|
Lambert, E., Saha, O., Soares, Landeira, B., et al. (2022) The Alz-heimer Susceptibility Gene BIN1 Induces Isoform-Dependent Neurotoxicity through Early Endosome Defects. Acta Neuropathologica Communications, 10, Article No. 4. https://doi.org/10.1186/s40478-021-01285-5
|
[38]
|
Zhao, J., Fu, Y., Yamazaki, Y., et al. (2020) APOE4 Exacerbates Synapse Loss and Neurodegeneration in Alzheimer’s Disease Patient IPSC-Derived Cerebral Organoids. Nature Communications, 11, Article No. 5540.
|
[39]
|
Fiock, K.L., Smalley, M.E., Crary, J.F., et al. (2020) Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. Eneuro, 7, No. 3. https://doi.org/10.1523/ENEURO.0058-20.2020
|
[40]
|
Walter, J., Bolognin, S., Poovathingal, S.K., et al. (2021) The Parkinson’s-Disease-Associated Mutation LRRK2-G2019S Alters Dopaminergic Differentiation Dynamics via NR2F1. Cell Reports, 37, Article ID: 109864.
https://doi.org/10.1016/j.celrep.2021.109864
|
[41]
|
Wulansari, N., Darsono, W.H.W., Woo, H.J., et al. (2021) Neurodevelopmental Defects and Neurodegenerative Phenotypes in Human Brain Organoids Carrying Parkinson’s Disease-Linked DNAJC6 Mutations. Science Advances, 7, Eabb1540. https://doi.org/10.1126/sciadv.abb1540
|
[42]
|
Zagare, A., Barmpa, K., Smajic, S., et al. (2022) Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-P.Gly2019Ser-Associated Gene Expression. The American Journal of Human Genetics, 109, 311-327. https://doi.org/10.1016/j.ajhg.2021.12.009
|
[43]
|
Boussaad, I., Obermaier, C.D., Hanss, Z., et al. (2020) A Patient-Based Model of RNA Mis-Splicing Uncovers Treatment Targets in Parkinson’s Disease. Science Translational Medicine, 12, Eaau3960.
https://doi.org/10.1126/scitranslmed.aau3960
|
[44]
|
Szebényi, K., Wenger, L.M.D., Sun, Y., et al. (2021) Human ALS/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology. Nature Neuroscience, 24, 1542-1554.
https://doi.org/10.1038/s41593-021-00923-4
|
[45]
|
Brighi, C., Salaris, F., Soloperto, A., et al. (2021) Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO IPSCs. Cell Death & Disease, 12, Article No. 498.
https://doi.org/10.1038/s41419-021-03776-8
|
[46]
|
Kang, Y., Zhou, Y., Li, Y., et al. (2021) A Human Forebrain Organoid Model of Fragile X Syndrome Exhibits Altered Neurogenesis and Highlights New Treatment Strategies. Na-ture Neuroscience, 24, 1377-1391.
https://doi.org/10.1038/s41593-021-00913-6
|
[47]
|
Achuta, V.S., Möykkynen, T., Peteri, U.K., et al. (2018) Func-tional Changes of AMPA Responses in Human Induced Pluripotent Stem Cell-Derived Neural Progenitors in Fragile X Syndrome. Science Signaling, 11, Eaan8784.
https://doi.org/10.1126/scisignal.aan8784
|
[48]
|
Park, J.C., Jang, S.Y., Lee, D., et al. (2021) A Logical Net-work-Based Drug-Screening Platform for Alzheimer’s Disease Representing Pathological Features of Human Brain Organoids. Nature Communications, 12, Article No. 280.
https://doi.org/10.1038/s41467-020-20440-5
|
[49]
|
Hunt, J.F.V., Li, M., Risgaard, R., et al. (2021) High Through-put Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells. Cells, 11, Article No. 69. https://doi.org/10.3390/cells11010069
|
[50]
|
Shou, Y., Liang, F., Xu, S., et al. (2020) The Application of Brain Organoids: From Neuronal Development to Neurological Diseases. Frontiers in Cell and Developmental Biology, 8, Article ID: 579659.
https://doi.org/10.3389/fcell.2020.579659
|