非侵袭性真菌性鼻窦炎的研究进展

doi:10.12677/ACM.2023.132197

期刊菜单

非侵袭性真菌性鼻窦炎的研究进展
Research Progress of Non-Invasive Fungal Sinusitis

DOI: 10.12677/ACM.2023.132197, PDF, HTML, XML, 下载: 348 浏览: 477
作者: 王柯柯, 张英^*：青海大学附属医院耳鼻咽喉科学，青海西宁
关键词: 非侵袭性真菌性鼻窦炎；免疫学特性；组织病理学特征；诊断；治疗；综述；Non-Invasive Fungal Sinusitis； Immunological Characteristics； Histopathological Characteristics； Di-agnosis； Treatment； Overview

摘要: 非侵袭性真菌性鼻窦炎多由于鼻窦被霉菌感染所引起的病理性免疫炎症反应。传统观点认为，非侵袭性霉菌性鼻窦炎(Non-invasive fungal rhinosinusitis, NIFS)的发生多与抗生素的广泛使用、环境污染，免疫抑制剂及抗肿瘤药物或放疗等相关，也可以在机体抵御侵袭能力下降的某一局部致病时发生。但近年来发现，在健康体检中亦可发现真菌性鼻窦炎，造成这种情况的原因尚不清楚，有待进一步研究。由于鼻窦炎的发病因素较为复杂，免疫性因素、组织病理反应、诊断及治疗等各有其特点，现就NIFS的免疫学特性、组织病理学特征、影像学诊断及治疗方法的研究进展作一综述。

Abstract: Non invasive fungal sinusitis is usually caused by pathological immune inflammation caused by fungal infection of the sinuses. According to the traditional view, the occurrence of non-invasive fungal rhinosinusitis (NIFS) is mostly related to the widespread use of antibiotics, environmental pollution, immunosuppressants, anti-tumor drugs or radiotherapy, and can also occur when the body’s ability to resist invasion decreases in a certain part of the disease. However, in recent years, it has been found that fungal sinusitis can also be found in the physical examination of healthy indi-viduals. The cause of this situation is still unclear and needs further research. Because the patho-genic factors of nasosinusitis are complex, and the immune factors, histopathological reactions, di-agnosis and treatment have their own characteristics, this article reviews the research progress of the immunological characteristics, histopathological characteristics, imaging diagnosis and treat-ment methods of NIFS.

文章引用：王柯柯, 张英. 非侵袭性真菌性鼻窦炎的研究进展[J]. 临床医学进展, 2023, 13(2): 1426-1433. https://doi.org/10.12677/ACM.2023.132197

参考文献

[1]	隋文君, 胡旭辰, 刘向祎. 慢性真菌性鼻-鼻窦炎病原学分析[J]. 国际检验医学杂志, 2022, 43(7): 786-790.
[2]	李健, 骆莹莹. 鼻内镜下治疗82例非侵袭性真菌性鼻窦炎的临床评价[J]. 饮食保健, 2020, 7(22): 45-46.
[3]	Lan, M.Y. (2021) Invasive Fungal Rhinosinusitis with and without Orbital Complications: Clinical and La-boratory Differences. Journal of Fungi, 7, 42-46. https://doi.org/10.3390/jof7070573
[4]	张蕾, 郭岳翰. 非侵袭性真菌性鼻-鼻窦炎发病影响因素及临床特点分析[J]. 湖北医药学院学报, 2021, 14(1): 60-62.
[5]	Mohammadi, A., Hashemi, S.M., Abtahi, S.H., et al. (2017) An Investigation on Non-Invasive Fungal Sinusitis; Molecular Identifica-tion of Etiologic Agents. Journal of Research in Medical Sciences, 22, 67-69. https://doi.org/10.4103/jrms.JRMS_166_17
[6]	房红娟, 马辉娟, 李晓瑞, 等. 血清变应原特异性IgE和外周血嗜酸粒细胞在霉菌性鼻窦炎中的表达及临床意义[J]. 川北医学院学报, 2021, 36(4): 429-432.
[7]	桂金乐, 刘志军, 周小林. 鼻内窥镜下息肉切除术后奥马珠单抗皮下注射治疗EOS阳性的慢性鼻-鼻息肉鼻窦炎效果观察[J]. 山东医药, 2021, 61(30): 79-82.
[8]	Stoop, A., Vanderheijden, H., Biewenga, J., et al. (1993) Eosinophils in Na-sal Polyps and Nasal Mucosa: An Immunohistochemical Study. Journal of Allergy & Clinical Immunology, 91, 616-622. https://doi.org/10.1016/0091-6749(93)90267-J
[9]	谢晓兴, 熊高云, 沈强, 等. 变应性因素对慢性鼻-鼻窦炎患者血清IgE及预后的影响[J]. 现代实用医学, 2018, 30(2): 244-245.
[10]	刘言军. 局部tIgE和真菌sIgE在鼻窦炎症性疾病中的表达及临床意义[D]: [硕士学位论文]. 合肥: 安徽医科大学, 2016, 43(37): 64-67.
[11]	曲滨, 李云川, 吕明刚. 血浆1,3-β-D葡聚糖联合免疫球蛋白指标检测对不同类型真菌性鼻窦炎诊断的临床意义[J]. 哈尔滨医科大学学报, 2018, 52(6): 584-587.
[12]	Corey, J.P., Delsupehe, K.G. and Ferguson, B.J. (1995) Allergic Fungal Sinusitis: Allergic, Infectious, or both? Otolaryngology—Head and Neck Surgery, 127, 110-113. https://doi.org/10.1016/S0194-5998(95)70153-2
[13]	王铭. 真菌性鼻窦炎诊断及治疗研究进展[J]. 医药前沿, 2019, 9(35): 8-10.
[14]	Waxman, J.E., Spector, J.G., Sale, S.R., et al. (1987) Allergic Aspergillus sinusitis: Concepts in Diagnosis and Treatment of a New Clinical Entity. Laryngoscope, 36, 261-265. https://doi.org/10.1288/00005537-198703000-00001
[15]	Sher, T.H. and Schwartz, H.G. (1988) Allergic Asper-gillus sinusitis with Concurrent Allergic Bronchopulmonary Aspergillosis: Report of a Case. Journal of Allergy and Clinical Immunology, 81, 844-846. https://doi.org/10.1016/0091-6749(88)90940-2
[16]	Tsimikas, S., Hollingsworth, H.M. and Nash, G. (1994) As-pergillus Brain Abscess Complicating Allergic Aspergillus sinusitis. Journal of Allergy and Clinical Immunology, 94, 264-269. https://doi.org/10.1053/ai.1994.v94.a52634
[17]	Brummund, W., Kurup, V.P., Harris, G.J., et al. (1986) Allergic Sino-Orbital Mycosis: A Clinical and Immunologic Study. JAMA, 256, 3249-3253. https://doi.org/10.1001/jama.1986.03380230073029
[18]	Gourley, D.S., Whisman, B.A., Jorgensen, N.L., et al. (1990) Allergic Bipolaris Sinusitis: Clinical and Immunopathologic Characteristics. Journal of Allergy and Clinical Im-munology, 85, 583-589. https://doi.org/10.1016/0091-6749(90)90097-N
[19]	Goldstein, M.F., Atkins, P.C., Cogen, F.C., et al. (1985) Al-lergic Aspergillus sinusitis. Journal of Allergy and Clinical Immunology, 76, 515-519. https://doi.org/10.1016/0091-6749(85)90737-7
[20]	王庄, 邢朝晖, 马小勇, 等. 功能性鼻窦内窥镜术后联合采用缓冲高渗盐溶液鼻腔冲洗对变应性鼻-鼻窦炎患者血清中IL-6、IL-8及IL-10的影响[J]. 中国卫生检验杂志, 2016, 26(21): 3134-3136, 3140.
[21]	王敏, 任海棠, 张劲, 等. 非侵袭性真菌性鼻-鼻窦炎患者免疫指标研究[J]. 中华医院感染学杂志, 2020, 30(5): 725-728.
[22]	戴如立, 骆映峰, 林广明. 鼻内镜手术治疗真菌球型真菌性后组鼻窦炎23例[J]. 广东医学院学报, 2010, 28(4): 438-439.
[23]	苏俊, 陶泽璋, 孔勇刚, 等. 真菌球型真菌性鼻-鼻窦炎55例临床分析[J]. 临床耳鼻咽喉头颈外科杂志, 2007, 21(23): 1075-1077.
[24]	Katzenstein, A.L.A., Sale, S.R. and Greenberger, P.A. (1983) Allergic Aspergillus sinusitis: A Newly Recognized Form of Sinusitis. Journal of Al-lergy and Clinical Immunology, 72, 89-94. https://doi.org/10.1016/0091-6749(83)90057-X
[25]	Corey, J.P., Delsupehe, K.G. and Ferguson, B.J. (1995) Al-lergic Fungal Sinusitis: Allergic, Infectious. Otolaryngology—Head and Neck Surgery, 113, 110-114. https://doi.org/10.1016/S0194-5998(95)70153-2
[26]	张杰, 马振岩. 霉菌性鼻窦炎的CT特征性表现与诊断效果分析[J]. 影像研究与医学应用, 2019, 3(10): 65-66.
[27]	Weiss, F., Habermann, C.R., Welger, J., et al. (2016) MRI in the Preoperative Diagnosis of Chronic Sinusitis: Comparison with CT. RoFo: Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 173, 319-324. https://doi.org/10.1055/s-2001-12458
[28]	陈军. 变应性真菌性鼻窦炎的CT影像学特征分析[J]. 深圳中西医结合杂志, 2020, 30(11): 66-67.
[29]	周亮辉, 陈月媚. 非侵袭性真菌性鼻窦炎患者应用鼻内窥镜辅助治疗的有效性及安全性分析[J]. 医学食疗与健康, 2021, 19(24): 64.
[30]	董继冰. 鼻内镜手术, 氟康唑联合两种糖皮质激素鼻喷雾剂治疗变应性真菌性鼻-鼻窦炎的效果及安全性对比[J]. 当代医药论丛, 2021, 19(24): 111-113.
[31]	陈霞, 张飞, 舒俊华. 皮下特异性免疫治疗儿童慢性变态反应性鼻-鼻窦炎对视觉模拟量表评分和Lund-Kennedy鼻内镜评分的影响[J]. 儿科药学杂志, 2022, 28(2): 46-48.
[32]	黄朝辉. 地塞米松联合鼻窦内窥镜治疗真菌性鼻窦炎患者的效果及不良反应率分析[J]. 中国保健营养, 2020, 30(30): 256-260.
[33]	何子瑜. 手术佐用抗真菌药物治疗真菌性鼻-鼻窦炎的疗效观察[J]. 中国医药指南, 2013, 6(2): 147-148.
[34]	马祖国, 胡伟. 鼻内镜低温等离子辅助下鼻窦手术联合抗真菌药物治疗真菌性鼻-鼻窦炎的疗效观察[J]. 中国基层医药, 2013, 20(14): 2117-2118.
[35]	刘燕青, 田兴德. 真菌性鼻鼻窦炎研究进展[J]. 长江大学学报(自科版)医学卷, 2008, 7(3): 88-90.
[36]	程可佳, 汪审清. 非侵袭性霉菌性鼻窦炎的诊治探讨[J]. 浙江预防医学, 2005, 17(1): 72-73.
[37]	Mabry, T.J., Markham, K.R. and Thomas, M.B. (1970) The Systematic Identification of Flavonoids. Springer, Berlin. https://doi.org/10.1007/978-3-642-88458-0
[38]	Greenhaw, R., Barnes, S., Pate, D., et al. (2005) The New FAA Flight Systems Laboratory’s Impact on Flight Procedure Design. AIAA Modeling and Simulation Technologies Confer-ence and Exhibit, San Francisco, 15-18 August 2005, 1. https://doi.org/10.2514/6.2005-5880
[39]	Melzer, L.V. and Groop, L. (2011) DNA Variations, Impaired Insulin Secretion and Type 2 Diabetes. Springer, New York, 53-57.
[40]	Doellman, M.S., Dion, G.R., Weitzel, E.K., et al. (2013) Immunotherapy in Allergic Fungal Sinusitis: The Controversy Continues. A Recent Review of Literature. Allergy & Rhinology, 4, e32-e35. https://doi.org/10.2500/ar.2013.4.0045
[41]	郭伟, 姜玉新. 变应原特异性免疫治疗的研究进展[J]. 中国人兽共患病学报, 2019, 35(4): 334-337.
[42]	于宙, 王丽娟. 三拗汤合苍耳子散辅助治疗儿童变应性鼻炎的效果及对患儿血清IgE水平, EOS水平和Th1/Th2细胞因子水平的影响[J]. 中国医学创新, 2019, 16(22): 84-88.
[43]	彭元志. 霉菌性鼻窦炎CT表现[J]. 中国现代医生, 2008, 46(8): 131-132.
[44]	冯世斌, 赵存尧, 刘荣松. 鼻内镜下上颌窦自然开口扩大术联合泪前隐窝入路切除术治疗非侵袭性真菌性鼻窦炎的疗效观察[J]. 河北医学2020, 26(12): 1995-1999.
[45]	熊颖, 袁琨. 非侵袭性真菌性鼻窦炎的诊疗方法及疗效分析[J]. 中华医院感染学杂志, 2012, 22(5): 982-983.

为你推荐

友情链接