水凝胶在药物缓释中的应用
The Application of Hydrogels in Drug Controlled Release
DOI: 10.12677/CC.2018.23013, PDF,  被引量   
作者: 朱钦麟, 李 英：山东大学，化学与化工学院，山东 济南
关键词: 水凝胶；药物缓释；透明质酸；表面活性剂；壳聚糖；Hydrogels； Controlled Release； Hyaluronic Acid； Surfactant； Chitosan
摘要: 药物缓释剂可以减少病人的给药次数，还使病人体内药物浓度稳定，使患者易于耐受。水凝胶具有良好的生物相容性和生物可降解性，适于作为药物缓释的药物载体。本文不仅阐述了水凝胶在药物控制释放体系方面的优势，而且概述了不同制备方法对应水凝胶在药物缓释上的应用。除此之外，本文还阐述了新型的水凝胶搭载疏水性药物的方法。
Abstract: We can minimize administration frequency and make drug consistence in blood steady by the ap-plication of drug sustained release. Hydrogels have excellent properties of biocompatibility and biodegradability, which are suitable vehicles for drug delivery systems. This paper not only de-scribed the advantages of hydrogels in drug controlled release, but also summarized the application of hydrogels prepared by different methods in drug controlled release. Beyond that, this paper described an innovative approach for the controlled release of hydrophobic drugs.
文章引用：朱钦麟, 李英. 水凝胶在药物缓释中的应用[J]. 比较化学, 2018, 2(3): 109-113. https://doi.org/10.12677/CC.2018.23013

参考文献

[1] Vallet-Regi, M., Balas, F. and Arcos, D. (2007) Mesopourous Materials for Drug Delivery. Angewandte Chemie In-ternational Edition in English, 46, 7548-7558. [Google Scholar] [CrossRef] [PubMed]
[2] Li, T., Evans, A.T., Chiravuri, S., et al. (2012) Compact, Power-Efficient Architectures Using Microvalves and Microsensors, for Intrathecal, Insulin, and Other Drug Delivery Systems. Advanced Drug Delivery Reviews, 64, 1639-1649. [Google Scholar] [CrossRef] [PubMed]
[3] Yu, L. and Ding, J.D. (2008) Injectable Hydrogels as Unique Biomedical Materials. Chemical Society Reviews, 37, 1473-1481. [Google Scholar] [CrossRef] [PubMed]
[4] Tang, Y.Q., Heaysman, C.L., Willis, S. and Lewis, A.L. (2011) Physical Hydrogels with Self-Assembled Nanostructures as Drug Delivery Systems. Expert Opinion on Drug Delivery, 8, 1141-1159. [Google Scholar] [CrossRef] [PubMed]
[5] Lee, K.Y. and Yuk, S.S. (2007) Polymeric Protein Delivery Systems. Progress in Polymer Science, 32, 669-697. [Google Scholar] [CrossRef] 
[6] Branco, M.C. and Schneider, J.P. (2009) Self-Assembling Materials for Therapeutic Delivery. Acta Biomaterialia, 5, 817-831. [Google Scholar] [CrossRef] [PubMed]
[7] 王萃萃, 杨伟平, 许戈文. 水凝胶的应用与研究进展[J]. 精细石油化工进展, 2010(98): 60-63.
[8] Zhao, X. and Harris, J.M. (1998) Novel Degradable Poly (Ethylene Glycol) Hydrogels for Controlled Release of Protein. Journal of Pharmaceutical Sciences, 97, 1450-1485. [Google Scholar] [CrossRef] [PubMed]
[9] Stauffer, S.R. and Peppas, N.A. (1992) Poly (Vinyl Alcohol) Hydrogels Prepared by Freezing-Thawing Cyclic Processing. Polymer, 33, 3932-3936. [Google Scholar] [CrossRef] 
[10] Ling, P.X. and He, Y.L. (1998) The Developing Progress of Sodium Hyaluronate in Clinical Application. Chinese Journal of Biochemical Pharmaceutics, 19, 200-204.
[11] Adam, M.E. (1998) Viscosupplementation as Articular Therapy. In: Laurent, T.C., Ed., The Chemistry, Biology and Medical Application of Hyaluronan and Its Derivatives, Portland Press, London, 243-254, 325-326.
[12] Balazs, E.A. (1966) Sediment Volume and Viscoelastic Behavior of Hyaluronic Acid Solutions. Federation Proceedings, 25, 1817-1822.
[13] Lu, L.P., Lai, J.Y., Ma, D.H.K., et al. (2015) Carbodiimide Cross-Linked Hyaluronic Acid Hydrogels as Cell Sheet Delivery Vehicles: Characterization and Interaction with Corneal Endothelial Cells. Polymer (Korea), 39, 976-980.
[14] Jean, B., Oss-Ronen, L., Terech, P. and Talmon, T. (2005) Monodisperse Bile-Salt Nanotubes in Water: Kinetics of Formation. Advanced Materials, 17, 728-731. [Google Scholar] [CrossRef] 
[15] Terech, P., Jean, B. and Ne, F. (2006) Hexagonally Ordered Ammonium Lithocholate Self-Assembled Nanotubes with Highly Monodisperse Sections. Advanced Materials, 18, 1571-1574. [Google Scholar] [CrossRef] 
[16] 宋沙沙. 表面活性剂水凝胶形成机理, 刺激响应性质与应用研究[D]: [博士学位论文]. 山东: 山东大学胶体与界面化学, 2015: 32-36.
[17] 那海秋, 刘宝忠, 张德智. 壳聚糖的性质、制备及应用[J]. 辽宁化工, 1997, 26(4): 194.
[18] Felt, O., Buri, P. and Gurny, R. (1998) Chitosan: A Unique Polysaccharide for Drug Delivery. Drug Devel-opment and Industrial Pharmacy, 24, 979-993. [Google Scholar] [CrossRef] [PubMed]
[19] Felt, O., Furrer, P., Mayer, J.M., et al. (1999) Topical Use of Chitosan in Ophthalmology: Tolerance Assessment and Evaluation of Precorneal Retention. International Journal of Pharmaceutics, 180, 185-193. [Google Scholar] [CrossRef] 
[20] Elinor, J., Meital, Z. and Havazelet, B. (2010) Composite Alginate Hydrogels: An Innovative Approach for the Controlled Release of Hydrophobic Drugs. Acta Biomaterialia, 6, 4642-4649. [Google Scholar] [CrossRef] [PubMed]
[21] 戴震, 王萃萃, 刘浏, 许戈文. 聚氨酯水凝胶概述[J]. PU Technology, 2009, 90: 70-73.
[22] 王立君, 张丽华. 智能水凝胶的发展现状[J]. 合成技术及应用, 2007, 22(9): 43-45.