Abstract:
Objective: Research on the preparation of puerarin capsule and the establishment of its in vitro Analytical Method. Method: Ultraviolet spectrophotometry method is adopted to analyze the impact of different excipients on dissolution rate of puerarin capsule. Results: The dissolution rate of puerarin capsule is optimal when the excipient formula consists of micro crystal cellulose (MCC), PEG-4000 and micronization silica gel. The in vitro accumulative dissolution rate reaches NLT 85% within 45 minutes. The UV standard curve shows a good linearity range between 1.0 - 10.0 µg/mL and the recovery rate is between 98.60% - 101.91%, RSD = 1.95%. Conclusion: The puerarin phosphatide capsule in this research has a good in vitro dissolution, which can be used as an in vivo assessment of the bioavailability to some extent. The ultraviolet spectrophotometry analytical method is easy to operate, fast, precise and accurate, which can be used as an in vitro analytical method for puerarin capsule.