摘要:
钙离子是细胞内广泛存在的第二信使，控制着几乎所有的生命过程。本文以钙信号的生物背景为基础，首先介绍了构建钙离子信号网络模型的数学方法，包括生化反应建模、参数拟合等；接着我们介绍了关于1，4，5-三磷酸肌醇受体(IP3R)通道和线粒体钙单向转运体(MCU)通道的各种模型；然后我们讨论了关于钙离子信号震荡的各种点源模型，包括内质网释放的钙信号震荡模型和内质网-线粒体相互作用调控的钙信号震荡模型；最后我们建议未来对钙信号相关的细胞信号网络建模展开进一步的研究。
Abstract:
The calcium ions (Ca2+) are the second messengers which are ubiquitous in cells, regulating almost all the cellular processes. In this review, based on the biological background of Ca2+ signaling, we first introduce the mathematical methods for the construction of Ca2+ signaling models, including modeling of biochemical reactions and parameter fitting. Next, we discuss in detail the modeling of Ca2+ channels, including the 1, 4, 5-trisphosphate receptor channel (IP3R) and mitochondrial Ca2+ signaling uniporter (MCU). Then we discuss various point source models of Ca2+ signal oscillations controlled by endoplasmic reticulum (ER) or the cross talk between ER and Mitochondria. Possible trends of modeling of Ca2+ signal in cellular signaling networks are also suggested.