卡他西醇和卤米松联合NB-UVB治疗寻常型银屑病

Tacalcitol and Sicorten Combined NB-UVB Treatment of Psoriasis Vulgaris

摘要: 目的：评价卡他西醇和卤米松联合窄谱中波紫外线局部外用治疗寻常型银屑病的临床观察。方法：获得随访的114例患者随机分成2组，69例予他卡西醇和卤米松局部外用作联合窄谱中波紫外线作为实验组，并选择同期45例单纯使用他卡西醇和卤米松局部外用作为对照组，比较两组患者2周、4周和8周后的临床疗效。结果：治疗2周时两组的评分差异不显著(P > 0.05)，但治疗4周和8周时PASI评分差异显著(P < 0.05)，治疗8周后有效率达85.7%，明显高于对照组(64.80%, P < 0.05)，且不良反应发生率低。结论：卡他西醇和卤米松局部联合窄谱中波紫外线治疗寻常型银屑病疗效确切，安全性好。

Abstract: Objective: To evaluate the curative effects of tacalcitol and sicorten on psoriasis vulgaris combined with narrow-spectrum midwave ultra-violet (NB-UVB). Methods: 114 cases were fractionated into two groups randly. The 69 cases of the experimental group were treated by tacalcitol and sicorten plus NB-UVB radiation, and 45 cases of the control group were treated by tacalcitol and sicorten. The clinical effect of two groups of patients was compared with eight weeks after 2 weeks. Results: The difference of two sets was quiet after 2 weeks management (P > 0.05), but the difference was significant after 4 and 8 weeks management (P < 0.05). The effective power of experimental group reached 85.70% after 8 weeks therapy. It was obviously top to the control group (64.80%, P < 0.05), and the incidence rate of untoward reaction was low. Conclusion: The combination of tacalcitol and sicorten plus NB-UVB phototherapy was a safe and effective method for treating psoriasis vulgaris.