气相色谱/ECD法检测苯丙胺类毒品

Studies on Detection of Amphetamines by Gas Chromatography/ECD

摘要: 本文探究了气相色谱法的电子俘获检测器测定苯丙胺类毒品的方法。在一定色谱条件下利用苯丙胺、甲基苯丙胺、伪麻黄碱标准溶液绘制苯丙胺类毒品的标准曲线，得到苯丙胺的标准曲线为y = 5.36x − 690.98，R = 0.9994，线性范围为2.0 × 10² μg∙mL⁻¹~1.0 × 10³ μg∙mL⁻¹，检出限为2.0 × 10² μg∙mL⁻¹，相对标准偏差为9.83%，甲基苯丙胺的标准曲线为y = 1.34x + 215.8，R = 0.9980，线性范围为2.0 × 10² μg∙mL⁻¹~2.0 × 10³ μg∙mL⁻¹，检出限为2.0 × 10² μg∙mL⁻¹，相对标准偏差为6.29%，伪麻黄碱的标准曲线为y = 8.07x + 176.38，R = 0.9988，线性范围为6.4 × 10⁻¹ μg∙mL⁻¹~4.0 × 10² μg∙mL⁻¹，检出限为6.4 × 10⁻¹ μg∙mL⁻¹，相对标准偏差为5.69%；并检测缴获的苯丙胺类毒品的有效成分及其含量。采用分散液相微萃取技术提取上述三种毒品，其平均回收率为39.70%、51.68%、65.05%。本文为法庭科学提供了检测苯丙胺类毒品的新方法。

Abstract: This paper studies the way to detect amphetamines with the use of gas chromatography, or to be specific, the electron capture detector method. By detecting amphetamine, methamphetamine and pseudoephedrine under a certain condition, the standard curves were drawn. The standard curve of amphetamine is y = 5.36x − 690.98, R = 0.9994. Its linearity range is 2.0 × 10² μg∙mL⁻¹~1.0 × 10³ μg∙mL⁻¹. Its detection limit is 2.0 × 10² μg∙mL⁻¹ and its RSD is 9.83%. The standard curve of me-thamphetamine is y = 1.34x + 215.83, R = 0.9980. Its linearity range is 2.0 × 10² μg∙mL⁻¹~2.0×10³ μg∙mL⁻¹. Its detection limit is 2.0×10²μg∙mL⁻¹ and its RSD is 6.29%. The standard curve of pseu-doephedrine is y = 8.07x + 176.38, R = 0.9988. Its linearity range is 6.4 × 10⁻¹ μg∙mL⁻¹~4.0 × 10² μg∙mL⁻¹. Its detection limit is 6.4 × 10⁻¹ μg∙mL⁻¹ and its RSD is 5.69%. Some drugs seized by local police were analyzed and their active ingredients and contents were defined. Amphetamines were extracted with dispersive liquid-liquid microextraction (DLLME) and the results showed that the average recovery of amphetamine is 39.70%, methamphetamine’s is 51.68% and pseudoephe-drine’s is 65.05%. This article can provide as reference for judicial detecting of amphetamines.