基本情况

蒋伶活，江南大学生物工程学院教授。国际期刊FEMS Yeast Research和Microbiological Research编委会成员；中国微生物学会真菌专业委员会委员；江苏省细胞与发育生物学会理事。曾兼任中国农科院研究员/博士生导师和天津市基础医学研究中心PI/博士生导师。


研究领域

酵母菌和丝状真菌的分子和细胞生物学、遗传学和功能基因组学、基因工程、代谢工程和发酵技术等


教育背景

2002年   博士后，加拿大国家科学院生物技术研究所

1999年   博士，加拿大阿尔伯塔大学分子生物学

1988年   硕士，中国农业大学和中国科学院微生物研究所合作培养病毒学

1985年   学士，南京农业大学植物病理学



工作经历

2011年5月至今，教授、博士生导师，江南大学生物工程学院

2004年5月至2004年11月，访问教授，美国哈佛大学Dana-Farber癌症研究所

2003年9月至2011年4月，教授、博士生导师，天津大学药物科学与技术学院

2002年6月至2003年8月，副研究员，美国佛吉利亚大学医学院药理系


论文发表

  1. Feng J, Zhao J, Li J, Zhang L, Jiang L (2010) Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans. Yeast, 27(9): 753-64
  2. Zhao J, Lin W, Ma X, Lu, Q, Ma X, Bian G, Jiang L (2010) The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in sporulation and meiosis as well as ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics, 95(5): 290-298
  3. Li X, Du W, Zhao J, Zhang L, Zhu Z, Jiang L (2010) The MAP kinase-activated protein kinase Rck2p regulates cellular responses to cell wall stresses, filamentation and virulence in the human fungal pathogen Candida albicans. FEMS Yeast Research, 10(4): 441-451
  4. Liu W, Zhao J, Li X, Li Y, Jiang L (2010) The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albicans. FEMS Yeast Research, 10(4): 462-470
  5. Jiang L, Zhao J, Guo R, Li J, Yu L, Xu D. (2010) Functional characterization and virulence study of ADE8 and GUA1 genes involved in the de novo purine biosynthesis in Candida albicans. FEMS Yeast Research, 10(2): 199-208
  6. Yu L, Zhao J, Feng J, Fang J, Feng C, Jiang Y, Cao Y, Jiang L (2010) Candida albicans CaPTC6 is a functional homolog for Saccharomycese cerevisiae ScPTC6 and encodes a type 2C protein phosphatase. Yeast, 27(4): 197-206
  7. Zhao J, Sun X, Fang J, Liu W, Feng C, Jiang L (2010) Identification and characterization of the type 2C protein phosphatase Ptc4p in the human fungal pathogen Candida albicans. Yeast, 27(3): 149-157
  8. Wang X, Cui Y, Fan F, Song Y, Ren J, Meng Q, Xu W, Jiang L (2010) Phylogenetic, carbendazim sensitivity and mycotoxin genotype analyses of Fusarium graminearum complex species isolated from wheat Fusarium head blight in China. Journal of Phytopathology, 158(7-8): 576-578
  9. Zhang D, Fan F, Yang J, Wang X, Qiu D, Jiang L(2010)FgTep1p is linked to the PI3 kinase signaling pathway and plays a role in the virulence of Fusarium graminearum on wheat. Molecular Plant Pathology, 11(4): 495-502
  10. Jiang L , Yang J, Fan F, Zhang D and Wang X. (2010) The Type 2C protein phosphatase FgPtc1p of the plant fungal pathogen Fusarium graminearum is involved in lithium toxicity and virulence. Molecular Plant Pathology, 11(2): 277-282
  11. 于立权，蒋伶活（2010）氧化胁迫环境下的酵母细胞应答调控，生命的化学，第1期
  12. 蒋伶活，于立权（2009）酿酒酵母丝氨酸/苏氨酸蛋白磷酸酯酶的功能与调控，生物技术通报，第12期17-21页
  13. 王继红，李西川，蒋伶活（2009）第10个溶质转运蛋白家族（SLC10）的细胞功能，细胞生物学杂志，第6期754-760页
  14. Fan J,Wu M,Jiang L,Shen SH (2009) A serine/threonine protein phosphatase-like protein, CaPTC8, from Candida albicans defines a new PPM subfamily. Gene, 430(1-2): 64-76
  15. 于立权，闫智慧，蒋伶活（2009）酿酒酵母ATP合酶δ亚基融合蛋白的构建、表达及生物学功能分析，生物技术通报，第8期99-103页
  16. 王继红，李西川，蒋伶活（2009）酵母细胞中ABC转运蛋白的分类和功能研究，细胞生物学杂志，第4期491-496页
  17. Li X, Huang X, Zhao J, Zhao J, Wei Y and Jiang L (2008) The MAP kinase-activated protein kinase Rck2p plays a role in rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans. FEMS Yeast Research, 8(5): 715-724
  18. Wan Y, Wang X, Huang Y, Qiu D and Jiang L (2008) Identification and characterization of cDNA sequences encoding the HIS3 and LEU2 genes of the fungus Alternaria tenuissima. Journal of Genetics and Genomics, 35(4): 251-256
  19. Zheng C, Yan Z, Liu W and Jiang L (2007) Identification and characterization of a functional Candida albicans homologue of Saccharomyces cerevisiae TCO89 gene. FEMS Yeast Research, 7(4): 558-568
  20. Wang J, Yan Z, Shen S-H, Whiteway M and Jiang L (2007) Expression of CaPTC7 is developmentally regulated during serum-induced morphogenesis in the human fungal pathogen Candida albicans. Canadian Journal of Microbiology, 53(2): 237-244
  21. Zheng C, Yan Z, Liu W and Jiang L (2007) Identification and characterization of a functional Candida albicans homologue of Saccharomyces cerevisiae TCO89 gene. FEMS Yeast Research 7(4): 558-68
  22. Feng F, Qiu D, Jiang L (2007) Isolation of cDNA sequences encoding the MAP kinase HOG1 and the MAP kinase kinase PBS2 genes of the fungus Alternaria tenuissima through a genetic approach. J Microbiol Methods. 69(1): 188-96
  23. 蒋伶活，闫智慧（2007）酵母TOR信号转导途径，细胞生物学杂志，第4期478-482页
  24. 赵炯，吕玮，段宏泉，蒋伶活（2007）高良姜中的抗白念珠菌化学成分，山西医科大学学报，第7期604-606页
  25. Ruan H, Yan Z, Sun H and Jiang L (2006) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Research, 7(2): 209-215
  26. 阮海华，李西川，兰蓓，蒋伶活（2006）高渗透压甘油（HOG）信号转导途径，细胞生物学杂志，第5期651-655页
  27. 吕玮，蒋伶活（2006）高良姜的化学成分及应用的研究进展，中国药业，3：19-20
  28. Jiang L, Niu S, Clines KL, Burke DJ and Sturgill TW. (2004) Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cervisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379. Molecular Genetics and Genomics, 271(2): 208-219
  29. Lee CM, Nantel A, Jiang L, Whiteway M and Shen SH (2004) The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans. Molecular Microbiology, 51(3): 691-709
  30. Jiang L, Whiteway M, Ramos CW, Rodriguez-Medina JR and Shen SH (2002) The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast. FEBS Letters, 527: 323-325
  31. Jiang L, Lee CM and Shen SH (2002) Functional characterization of the Candida albicans homologue of secretion associated and Ras-related (Sar1) gene. Yeast, 19(5): 423-428
  32. Jiang L, Whiteway M and Shen SH (2001) A novel type 2C protein phosphatase from the human fungal pathogen, Candida albicans. FEBS Letters, 509 (1): 142-144
  33. Jiang L and Hiruki C (1996): Polymerase chain reaction amplification and restriction analysis of the ribosomal DNA of Olpidium radicale isolates. J. Microbiol. Methods, 26(1-2): 87-93