基本情况

陈镜宇，博士，安徽医科大学临床药理研究所副教授，硕士生导师。曾主持国家自然基金、安徽省教育厅自然基金重点基金、安徽省教育厅优秀青年人才基金等项目。作为主要研究人员参加多个抗炎免疫药物的临床前药效学研究，在炎症免疫调节与药物靶点研究方面有一定的理论基础和研究经验。


研究领域

自身免疫病的免疫病理机制及药物靶点研究

 

工作经历

2023年12月至今，担任中国药理学会抗炎免疫药理专业委会委员、青委会委员、安徽省药理学会抗炎免疫药理专业委会委员。

2021年7月至今，担任安徽省药理学会临床药理专业委会委员。

 

科研项目

  1. 主持国家自然基金青年项目1项
  2. 安徽省教育厅自然基金重点基金项目1项
  3. 安徽省教育厅优秀青年人才基金项目1项
  4. 安徽省教育厅自然基金项目1项
  5. 安徽医科大学博士科研基金项目1项


论文发表

  1. Wang W, Xu X, Yang M, Jiang M, Wang D, Tang C, Wei W, Chen J. Ginsenoside Compound K Reduces Psoriasis-related Inflammation by Activation of the Glucocorticoid Receptor in Keratinocytes. Curr Mol Pharmacol. 2024;17:e18761429254358
  2. Mao L, Wei W, Chen J. Biased regulation of glucocorticoid receptors signaling. Biomed Pharmacother. 2023;165:115145. 
  3. Yang M, Mao L, Yang X, Xu X, Tang C, Wei W, Chen J. Ginsenoside compound K exerts anti-inflammatory effects through transcriptional activation and transcriptional inhibition of glucocorticoid receptor in rheumatoid arthritis fibroblast-like synoviocytes. Int Immunopharmacol. 2023;125(Pt A):111080.
  4. Jiang M, Tang C, Yang M, Li Y, Wang W, Wang C, Wei W, Chen J. Paeoniflorin-6'-O-benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β-arrestin 2 on ERK1/2-NF-κB. Phytother Res. 2023;37(2):743-758.
  5. Yang M, Chen J, Wei W. Dimerization of glucocorticoid receptors and its role in inflammation and immune responses. Pharmacol Res. 2021;166:105334
  6. Chen J, Wang W, Jiang M, Yang M, Wei W. Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats. Pharm Biol. 2020;58(1):1131-1139.
  7. Wang DD, Jiang MY, Wang W, Zhou WJ, Zhang YW, Yang M, Chen JY,Wei W. Paeoniflorin-6'-O-benzene sulfonate down-regulates CXCR4-Gβγ-PI3K/AKT mediated migration in fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting GRK2 tr anslocation. Biochem Biophys Res Commun. 2020;526(3):805-812.
  8. Wang D, Zhou W, Chen J, Wei W. Upstream regulators of phosphoinositide 3-kinase and their role in diseases. J Cell Physiol. 2019;10.1002/jcp.28215.
  9. Chen J, Si M, Wang Y, Liu L, Zhang Y, Zhou A, Wei W. Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2. Inflammopharmacology. 2019;27(1):157-166.
  10. Chen J, Wang Y, Wu H, Yan S, Chang Y, Wei W. A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice. Front Pharmacol. 2018;9:563.
  11. Chen J, Wang Q, Wu H, Liu K, Wu Y, Chang Y, Wei W. The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis. Pharm Biol. 2016;54(7):1280-8.
  12. Chen J, Wu H, Wang Q, Chang Y, Liu K, Wei W. Ginsenoside Metabolite Compound K Suppresses T-Cell Priming via Modulation of Dendritic Cell Trafficking and Costimulatory Signals, Resulting in Alleviation of Collagen-Induced Arthritis. J Pharmacol Exp Ther. 2015;353(1):71-9.
  13. Chen J, Wu H, Wang Q, Chang Y, Liu K, Song S, Yuan P, Fu J, Sun W, Huang Q, Liu L, Wu Y, Zhang Y, Zhou A, Wei W. Ginsenoside metabolite compound k alleviates adjuvant-induced arthritis by suppressing T cell activation. Inflammation. 2014;37(5):1608-15.
  14. Chen JY, Wu HX, Chen Y, Zhang LL, Wang QT, Sun WY, Wei W. Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled receptor kinase 2. Planta Med. 2012; 78(7):665-71.


参编专著

  1. 《实验研究方法学》（第四版），魏伟主编；人民卫生出版社；2021年出版。
  2. 《实验药理方法学》（第四版），魏伟主编；人民卫生出版社；2010年出版。
  3. 《临床药理学原理》魏伟主译，科学出版社，2008年出版。