基本情况
蔡禄，男，博士，教授。国务院特殊津贴专家、内蒙古自治区杰出人才，主持国家自然科学基金项目5项，教育部、内蒙古自治区等基金共26项；在国内外重要学术刊物发表科学论文292余篇，其中SCI、EI、ISTP 收录48篇。出版《表观遗传学前沿》学术专著1部，《生物信息学》教材3部。获得国家授权发明专利10项、实用新型专利8项。 获国家自然科学奖三等奖、内蒙古自治区自然科学奖一等奖、科技进步奖一等奖、科技进步奖二等奖各1项。中国细胞生物学学会功能基因组信息学与系统生物学分会委员、中国生物工程学会生物信息学与计算生物学分会委员。
教育经历
1980.09-1984.07 内蒙古大学物理系学习, 理学学士
1984.09-1987.07 内蒙古大学物理系学习, 生物物理学硕士
1996.09-2000.70 内蒙古大学物理系学习, 生物物理学博士
2000.09-2002.09 清华大学生物系, 生物信息学博士后
2002.10-2003.11
美国德克萨斯A & M大学系统健康科学中心，生物科学与技术研究所，访问学者。
2014.10-2015.04 美国凯斯西储大学医学院遗传学与基因组学系，访问学者
研究领域
生物信息学、表观遗传学、基因序列的信息学分析、DNA结构、蛋白质-蛋白质相互作用及网络等。目前主要关注基因表达调控在表观遗传学层面的调控机制，开展核小体定位、组蛋白修饰、RNA可变剪接等问题研究。
科研项目
1.国家自然科学基金面上项目，工业粉尘对大鼠肺巨噬细胞基因可变剪接的影响及生物效应（61671256），2017.1-2020.12
2.国家自然科学基金面上项目，可变剪接相关生物大分子相互作用网络的构建与分析（61271448），2013.1-2016.12
3.国家自然科学基金面上项目，基于基因组序列和结构特征的核小体定位的理论和实验研究（61072129）， 2010.1-2013.12
4.国家自然科学基金地区项目，基于蛋白质二级结构的蛋白质相互作用及网络的研究（60761001），2008.1-2010.12
5.国家自然科学基金地区项目，与人遗传病相关的DNA重复序列柔性的实验和理论研究（30460038），2005.1-2007.12
论文发表
1.Xing Y, Yang W, Liu G, Cui X, Meng H, Zhao H,
Zhao X, Li J, Liu Z, Zhang MQ and Cai L*.
Dynamic Alternative Splicing During Mouse Preimplantation Embryo
Development. Front. Bioeng.
Biotechnol. 2020, 8:35.
2.Hongyu Zhao, Fenghui Zhang, Mingxing Guo,
Yongqiang Xing, Guoqing Liu, Xiujuan Zhao, and Lu Cai*, The affinity of DNA sequences containing R5Y5 motif and TA
repeats with 10.5-bp periodicity to histone octamer in vitro. J Biomol
Struct Dyn. 2019, 37(8):1935-1943.
3.邢永强* 何泽学 刘国庆 蔡禄* 拟南芥不同组织基因表达及可变剪接差异分析. 生物化学与生物物理进展. 2019，46（11）:1118-1129.
4.Guoqing Liu, Yongqiang Xing, Hongyu Zhao, Lu Cai & Jianying Wang，The implication of DNA bending energy for
nucleosome positioning and sliding. Sci.
Rep. 2018, 8:8853
5.Guoqing Liu, Yongqiang Xing, Hongyu Zhao,
Jianying Wang, Yu Shang and Lu Cai*, A deformation energy-based model for
predicting nucleosome dyads and occupancy. Sci. Rep. 2016, 6:24133
6.Yongqiang Xing, Xiujuan Zhao, Tao Yu, Dong
Liang, Jun Li, Guanyun Wei, Guoqing Liu, Xiangjun Cui, Hongyu Zhao, Lu Cai*,
MiasDB: A Database of Molecular Interactions Associated with Alternative
Splicing of Human Pre-mRNAs. Plos One, 2016, 11(5): e0155443.
7.Xiang-Jun
CuiLu Cai, Yong-Qiang
Xing, Xiu-Juan
Zhao, Chen-Xia
Shi，Influence factors on the correlations between
expression levels of neighboring pattern genes. Biosystem, 2016, 139:23-28.
8.Guoqing Liu*, Yongqiang Xing, Lu Cai*. Using
weighted features to predict recombination hotspots in Saccharomy
cescerevisiae. Journal of Theoretical Biology, 2015, 382:15-22 (SCI, IF2.5)
9.Hongyu Zhao, Yongqiang Xing, Guoqing Liu,
Ping Chen, Xiujuan Zhao, Guohong Li*, Lu Cai*. GAA triplet-repeats cause
nucleosome depletion in the human genome. Genomics, 2015, 106:88-95
10.G-Q Liu* F Feng X-J Zhao and L Cai*,
Nucleosome Organization around Pseudogenes in the Human GenomeHindawi
Publishing Corporation. BioMed Research International 2015, Article ID
821596
11.Wantong Si, Jumei Liu, Lu Cai, Haiming Jiang,
Chunli Zheng, Xiaoying He and Jianying Wang. Health Risks of Metals in
Contaminated Farmland Soils and Spring Wheat Irrigated with Yellow River Water
in Baotou, China. Bull Environ Contam Toxicol (2015) 94:214–219
12.Alok Sharma, Hieu Nguyen, Lu Cai and Hua Lou,
Histone hyperacetylation and exon skipping: a calcium-mediated dynamic
regulation in cardiomyocytes. Nucleus, 2015, 6(4):273-278
13.Yongqiang Xing, Guoqing Liu, Xiujuan Zhao,
Hongyu Zhao and Lu Cai*, Genome-wide characterization and prediction of
Arabidopsis thaliana replication origins. Biosystem 2014, 124:1-6
14.Binjie Zang，Guoqing
Liu and Lu Cai, Predicting recombination hot/cold spots in Saccharomyces
cerevisiae from multiple information. Chinese SCI Bull. 2014; 59(11):953.
15.Yong-qiang Xing & Guo-qing Liu &
Xiu-juan Zhao &Lu Cai*，An analysis and
prediction of nucleosome positioning based on information content. Chromosome
Res. (2013) 21:63–74
16.Guoqing Liu; Jia Liu; Xiangjun Cui; Lu Cai,
Sequence-dependent prediction of recombination hotspots in Saccharomyces
cerevisiae J Theor. Biol. (2012) 293: 49-54
17.Yongqiang Xing Xiujuan Zhao and Lu Cai*,
Prediction of nucleosome occupancy in Saccharomyces cerevisiae using
position-correlation scoring function. Genomics (2011) 98:359-366
18.Jiantao Yu, Maozu Guo, Chris J. Needham,
Yangchao Huang, Lu Cai and David R. Westhead, Simple sequence-based kernels do
not predict protein-protein interactions. Bioinformatics (2010)
26(20):2610-2614
19.Xiujuan Zhao Zhiyong Pei Jia Liu and Lu Cai*,
Prediction of Nucleosome DNA Formation Potential and Nucleosome Positioning
Using Increment of Diversity Combined with Quadratic Discriminant Analysis,
Chromosome Res. (2010) 18:777-785
20.Guoqing Liu, Hong Li, Lu Cai.
Processed pseudogenes are located preferentially in regions of low
recombination rates in the human genome. (2010) J. Evol. Biol.
23(5):1107–1115.
21.S-H Kim, Lu Cai, M. J. Pytlos,
and R. R. Sinden, Ligation of (CAG)n•(CTG)n repeats flanked with only G and C
overhang ends produces long uninterrupted repeats in vitro. (2005)
BioTechniques 38(2) 247-253
22.Lu Cai, DNA Curvature of
(CCTG)n·(CAGG)n and (ATTCT)n·(AGAAT)n Repeats Sequences, (2005) International J
Mod. Phys. B 19(15-17) 2921-2926
23.Lu Tsai, Liaofu Luo and Zhirong
Sun, Sequence-dependent flexibility in promoter sequences. (2002) J.Biomolec.
Struc. Dynam. 20(1), 127-134
24.Lu Tsai and Zhirong Sun, The
dynamic flexibility in Escherichia coli genome. (2001). FEBS Letters
507(2),225-230.
25.Lu Tsai and Liaofu Luo, A
statistical mechanical model for predicting B-DNA curvature and flexibility
(2000, 11 月) J. Theor. Biol. 207,
177-194
26.Liaofu Luo, Weijiang Lee ,
Lijun Jia, Fengmin Ji and Lu Tsai, Statistical correlation of nucleotides in a
DNA sequence, Phys. Rev. E,1998,Vol.58,No.1,861
27.Liaofu Luo Lu Tsai and Weijiang
Lee, Model of evolution of Molecular Sequence, Phys. Rev. A
,1990,Vol.41,5441-5450
28.L.F.Luo L.Tsai and Y.M.Zhou,The
informational parameters of nucleic acid and molecular evolution, J. Theor.
Biol.,1988,Vol.130,351-361
29.Luo Liaofu and Cai Lu，Squeezing effect from photon scattering，Chinese Phys. Lett. 1986, Vol.3 No.145-47
30.Luo Liaofu and Cai Lu，Fractal dimension of Nucleic Acid sequences and Its Relation to
Evolutionary Level,Chinese Phys. Lett.,1988,Vol.5,No.9,421