基本情况

郭修晗，大连理工大学化工与环境生命学部，副教授。

研究方向

1. 生理活性化合物的化学生物学研究
2. 天然活性化合物的探索及全合成研究
3. 基于肿瘤微环境的选择性抗肿瘤活性化合物的发现

教育背景

2017年12月 副教授，化工与环境生命学部制药科学与技术学院

2013年5月 讲师，化工与环境生命学部

2008年10月 博士，日本大阪大学药学研究科

2004年9月 硕士，大连理工大学化院

发表论文

1. Xiuhan Guo, Rui Cai, Shisheng Wang, Bo Tang, Yueqing Li and Weijie Zhao*, Non-destructive geographical traceability of sea cucumber (Apostichopus japonicus) using near infrared spectroscopy combined with chemometric methods. R. Soc. open sci., 2018,5,171581,DOI: 10.1098/rsos.171581
2. Xiuhan Guo,Liu Wang,Shisheng Wang*,Yueqing Li,Lei Cao,Rui Cai, Weijie Zhao,Synergistic antiproliferative effect of chemo-phototherapy: Synthesis and photodynamic activity evaluation of novel Chlorin e6-artesunate onjugates as antiproliferative agents,Bioorg. Med.Chem.Lett.,2017, 27(19): 4548-4551
3. Lei Cao,Xiuhan Guo,Liu Wang,Shisheng Wang,Yueqing Li, Weijie Zhao*,Synthesis and in vitro phototoxicity of novelπ-extension derivatives of chlorin e6,New J.Chem,2017,41, 14279-14287
4. Ge Zhang,Xiuhan Guo, Shisheng Wang* ,Yueqing Li,Guangzhe Li, Weijie Zhao,Screening and identification of natural ligands of tyrosinase from Pueraria lobata Ohwi by a combination of ultrafiltration and LC-MS, Anal.Methods,2017,9(33): 4858-4862
5. Xiuhan Guo, Liu Wang, Shisheng Wang*, Yueqing Li, Zhang Fan, Song Bo, Weijie Zhao*, Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation, Bioorg. Med. Chem. Lett, 2015, 25(19): 4078-4081
6. 郭修晗，郑晓红，王世盛*，王迪，于远洋，赵伟杰，藜芦胺类似物的合成及体外抗肿瘤活性研究，精细化工，2015，32(11)：1266-1270
7. Zhi Cao,Yueqing Li,Shisheng Wang,Bo Tang,Xiuhan Guo,Liu Wang,Weijie Zhao*,Biomimetic synthesis of bis-α-substituent pyrrolidine alkaloids based on a proposed biosynthetic pathway, Tetrahedron Lett,2016,57(12):2219-2221
8. Zhi Cao,Yueqing Li,Shisheng Wang,Xiuhan Guo,Liu Wang,Weijie Zhao*,Total Synthesis of Two Pyrrole Spiroketal Alkaloids:Pollenopyrroside A and Capparisine B,Synlett,2015, 26(7):921-926
9. Naoyuki Kotoku, Nakata Chiaki, Kawachi Takashi, Sato Takanori, Xiuhan Guo, Ito Aoi, Sumii Yuji. Arai Masayoshi, Motomasa Kobayashi *, Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor. Bioorg. Med. Chem, 2014, 22:2102-2112
10. Naoyuki Kotoku,Xiuhan Guo,Masayishi Arai,Motomasa Kobayashi*,Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity. Bioorg.Med.Chem.Lett.2010,20(14): 4152-4155