基本情况

孙连坤，现为博士生导师、教授。专业为病理生理学，现任吉林大学基础医学院院长。中国病理生理学会/理事；中国病理生理学会肿瘤专业委员会/委员；吉林省生理科学会/副理事长；吉林省中西医结合学会第一届实验医学专业委员会/副主任委员；吉林省病理学与病理生理学重点实验室主任；吉林省天然药物药理药效与应用开发工程研究中心主任；吉林大学前列腺疾病防治研究中心主任；吉林省中医药科研实验室主任。吉林省高级专家；长春市第五批有突出贡献专家；宝钢教育基金优秀教师奖；长春市总工会/长春市师德标兵。

教育背景

1996年4月至2000年3月 博士，日本琉球大学医学部

1994年9月至1996年3月 硕士，日本琉球大学医学部

1987年9月至1990年7月 硕士，白求恩医科大学

1979年9月至1985年7月 学士，延边医学院

工作经历

2013年1月至今         教授、博士生导师，吉林大学

2007年2月至2012年12月 教授、博士生导师，吉林大学

2004年12月至2007年2月 教授、博士生导师，吉林大学

2003年4月至2004年11月 教授、博士生导师，吉林大学

2002年4月至2003年3月  研究员，日本基因芯片研究所  

1985年8月至1994年5月  助教、讲师，白求恩医科大学

学术成果

近年来，发表SCI论文40余篇。承担多项国自然基金。参与编写了五年制用及七八年制用【病理生理学】人民卫生出版社编写及副主编；【衰老、痴呆与预防医学新进展】副主编；《吉林大学学报（医学版》编辑委员会 副主任委员；《中华医学教育探索杂志》《病理生理杂志》编委。作为指导教师，在全国第一、第二、第三届大学生基础医学创新论坛暨实验设计大赛均获得一、二等奖 ；研究生获得吉林省优秀博士论文等。

论文发表

1. Shuang Gu,Xiao-Chun Yang, Xi-Yan Xiang, Yao Wu, Yu Zhang,Xiao-Yu Yan, Ya-Nan Xue, Lian-Kun Sun*, Guo-Guang Shao*. Sanguinarine- induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stressOncology Reports:913-9     2015.08（SCI IF：2.301*通讯作者）       
2. Fan Z, Yu H, Cui N, Kong X, Liu X, Chang Y, Wu Y, Sun L*, Wang G*.  ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics      Exp Cell Res   2015 July;335(1):68-81（SCI IF：3.246*通讯作者）                    
3. Jing Su, Fei Liu, Meihui Xia, Ye Xu, Xiaoning Li,Jinsong Kang, Yulin Li*, Liankun Sun*.    p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells Oncology Reports      235-432.3012015（SCI IF：2.301*通讯作者）
4. Yu-fei Gao, Guang-hu Li, Lian-kun Sun ; Yi-chun He, Xiao-yan -Li, Zhi Sun, Ji-han Wang), Yang Jiang, Jing-wei Shi.     ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain. BMC Cancer.   2015 Apr 12;15(1):277        
5. Xiao-chunYang,Xi-yan Xiang,Mei-hui Xia , Jing Su, Yao Wu, Lu-yan Shen , Ye Xu, Lian-kun Sun*.    Inhibition of JNK3 Promotes Apoptosis Induced by BH3 Mimetic S1 in Chemoresistant Human Ovarian Cancer Cells  Anat Rec (Hoboken)      2015 Feb;298(2):386-95（SCI IF：1.542*通讯作者）
6. Kong D, Zhao L, Du Y, He P, Zou Y, Yang L, Sun L, Wang H, Xu D, Meng X, Sun X.Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth     Int J Clin Exp Pathol.  2014Oct 15;7(11):7497-507
7. Jing Su , Lei Zhou, Mei-Hui Xia, Ye Xu, Xi-Yan Xiang, Lian-Kun Sun*. Bcl-2 family proteins are involved in the signal crosstalk between endoplasmic reticulum stress and mitochondrial dysfunction in tumor chemotherapy resistance.       Biomed Res Int.  2014;2014:234370. （SCI IF：1.579*通讯作者）
8. Yue Liu, Yan-mei Wang, Lian-kun Sun, Man-qi Zhang, Sheng-xu Xie, Dong-ming Xu, Ya-juan Xu. Steroidal Glycosides from the Fruits of Tribulus terrestris.  CHEMISTRY OF NATURAL COMPOUNDS 2014,50（3）：483-488
9. YuxiongLu, JinsongKang ,YangBai, YuZhang, HongyanLi, XiaochunYang, XiyanXiang, XinxueWang, YuanpingHuang, JingSu, YeChen, Bingjin Li*, LiankunSun*. Hyperbaric oxygen enlarges the area of brain damage in MCAO rats by blocking autophagy via ERK1/2 activation. European Journal of Pharmacology 7 (728C) : 93-99, 2014. (SCI IF:2.592, *通讯作者)
10. Yan Song, Jinli Hou, Bin Qiao, Yanchao Li, Ye Xu, Ming Duan, Zhenhong Guan, Maolin Zhang*,Liankun Sun*. Street rabies virus causes dendritic injury and F-actin depolymerization in the hippocampus. J Gen Virol., 94(Pt 2):276-83, 2013. (SCI IF:3.127, *通讯作者)
11. Xiaoning Li, Jing Su, Lu Zhao, Jingbao Xiang, Wanhe Wang, Fei Liu, Hongyan Li, Jiateng Zhong, Xu Bai*, Liankun Sun*. The p38 MAPK inhibitor JLU1124 inhibits the inflammatory response induced by lipopolysaccharide through the MAPK-NF-κB pathway in RAW264.7 macrophages. Int Immunopharmacol.,17(3):785-792, 2013. (SCI IF:2.417, *通讯作者)
12. Ye Xu, Jinsong Kang, Zhaoxin Yuan, Hongyan Li, Jing Su, Yang Li, Xiaoxia Kong, Hongyu Zhang, Weiwei Wang, Liankun Sun*. Suppression of CLIC4/mtCLIC enhances hydrogen peroxide-induced apoptosis in C6 glioma cells. Oncol Rep., 29(4):1483-1491, 2013. (SCI IF:2.417, *通讯作者)
13. Ning Liu, Ye Xu, Jitong Sun, Jing Su, Xiyan Xiang, Haowei Yi, Zhichao Zhang, LianKun Sun*. The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy. Oncol Rep., 30(6): 2677-2684, 2013. (SCI IF:2.297, *通讯作者)
14. Jiateng Zhong, Shavali Shaik, Lixin Wan, Adriana E. Tron, Zhiwei Wang, Liankun Sun, Hiroyuki Inuzuka* and Wenyi Wei*. SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget, 4(12):2339-2353, 2013. (SCI IF:6.636，*通讯作者)
15. Weiwei Wang, Jinsong Kang, Hongyan Li, Jing Su, Jiang Wu, Ye Xu,  Huimei Yu, Xiyan Xiang, Haowei Yi, Yuxiong Lu, Liankun Sun*. Regulation of endoplasmic reticulum stress in rat cortex by p62/ZIP through the Keap1-Nrf2-ARE signalling pathway after transient focal cerebral ischaemia. Brain Inj., 27(7-8):924-933, 2013. (SCI IF:1.513, 通讯作者)
16. Ye Chen, Lu Zhao, Xiaowei Tian, Tingting Liu, Jiateng Zhong, Liankun Sun*, Jiamei Liu*.Autophagy Induced by the Withdrawal of Mitogens Promotes Neurite Extension in Rat Neural Stem Cells. J Biochem Mol Toxicol. , 27(7):351-356, 2013. (SCI IF:1.596, *通讯作者)
17. Jing Su, Lei Zhou, Xiaoxia Kong, Xiaochun Yang, Xiyan Xiang, Yu Zhang, Xiaoning Li, Liankun Sun*. Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus. J Diabetes Res., 2013:193461, 2013. (SCI IF:1.893, *通讯作者)
18. Chunyan Yu, Xiaowei Huang, Ye Xu, Hongyan LI, Jing Su, Jiateng Zhong, Jinsong Kang, Yuhe Liu, Liankun Sun*. Lysosome Dysfunction Enhances Oxidative Stress-Induced Apoptosis through Ubiquitinated Protein Accumulation in Hela Cells. Anat Rec (Hoboken). , 296(1):31-9,2013. (SCI IF:1.343, *通讯作者)
19. Jing Su, Ye Xu, Lei Zhou, Huimei Yu, Jinsong Kang, Ning Liu,Chengshi Quan, Liankun Sun*. Suppression of Chloride Channel 3 Expression Facilitates Sensitivity of Human Glioma U251 Cells to Cisplatin Through Concomitant Inhibition of Akt and Autophagy. Anat Rec (Hoboken)., 296(4):595-603, 2013. (SCI IF:1.343, *通讯作者)
20. Jiateng Zhong, Ye Xu, Haowei Yi, Jing Su, Huimei Yu, Xiyan Xiang, Xiaoning Li, Zhichao Zhang*, Liankun Sun*. The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. Cancer Lett., 323(2):180-187,2012. (SCI IF:4.258, *通讯作者)
21. Ye Xu, Huimei Yu, Hanjiao Qin, Jinsong Kang, Chunyan Yu,Jiateng Zhong, Jing Su, Hongyan Li, Liankun Sun*. Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells. Cancer Lett., 314:232-243,2012.(SCI IF:4.258, *通讯作者)
22. Jiateng Zhong, Xiaoxia Kong, Hongyu Zhang, Chunyan Yu, Ye Xu, Jinsong Kang, Huimei Yu, Haowei Yi, Xiaochun Yang, Liankun Sun*. Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis in human glioma U251 cells under starvation. PLoS One, 7(6):e39378, 2012. (SCI IF:3.73, *通讯作者)
23. Huimei Yu, Jing Su, Ye Xu, Jinsong Kang, Hongyan Li, Ling Zhang, Haowei Yi , Xiyan Xiang, Fei Liu, Liankun Sun*. p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins. European Journal of Cancer, 47:1585-1594,2011. (SCI IF:5.536, *通讯作者)
24. Ye Xu, Hua Zheng, JinSong Kang, Lei Zhang, Jing Su, HongYan Li, LianKun Sun*.  5-nitro-2-(3- phenylpropylamino) benzoic acid (NPPB) induced drug resistance to cisplatin in human erythroleukemia cell lines. Anatomical Record.,294:945-952，2011. (SCI IF:1.49, *通讯作者)