基本情况

张晓华，博士，美国默沙东医药研究院生物统计与科学决策部总监，博士后导师、高级研究员、生物统计与科学决策部副总监。曾任美国统计学会生物医药分会研究生文章竞赛年度评选委员会委；美国联合统计大会分组主持人兼组织人、中国香港国际生物信息学大会组委会委员、韩国首尔市国际信息科学与应用大会项目委员会委员、中国细胞生物学学会功能基因组信息学与系统生物学分会理事、欧盟框架卫生项目研究重大基金FP7的特邀评审专家、美国NIH基金特邀评审专家、中国江西省省科技进步二等奖获得者和主要负责人之一、概率与统计学报特辑的客座主编、生物测度与生物统计学报等专业杂志的编委


研究领域

高通量生物技术实验、数据分析及其在医药行业中的应用、个性化医学及个性化药物的创新研究、RNA干扰实验的数据分析及其在药物发现中的应用、生物信息学中的统计方法研究、药物动力学的统计方法研究


教育背景

1998年12月 博士，美国德州农工大学

1996年7月 硕士，北京师范大学

1990年7月 学士，北京师范大学


工作经历

1996年8月至1996年11月 讲师，中国江西医学院（现南昌大学）

1990年8月至1993年08月 助理工程师，中国江西省南昌市水产科研所


论文发表

  1. Gould AL, Zhang XHD. 2013. Bayesian adaptive determination of the sample size required to assure acceptably low adverse event risk. Statistics in Medicine(submitted)
  2. Zhang XHD, Zhang ZZ. 2013. displayHTS: a R package for displaying data and results from high-throughput screening experiments. Bioinformatics 29 (6): 794–796 (doi: 10.1093/bioinformatics/btt060)
  3. YangR, LacsonRG, CastriotaG, Zhang XHD, LiuY, ZhaoWQ, EinsteinM; Camargo, Luiz CM, Qureshi S, Wong KK, Zhang BB, FerrerM, Berger JP. 2012. A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis. PLoS ONE7(5): e36384. (doi:10.1371/journal.pone.0036384)
  4. Zhang XHD, Heyse JF. 2012. Contrast variable for comparing groups in biopharmaceutical research. Statistics in Biopharmaceutical Research 4 (3): 228 – 239 (DOI: 10.1080/19466315.2011.646905)
  5. Zhang XHD, SantiniF, Lacson R, MarineSD, WuQ, Benetti L, YangR, McCampbell A, Berger JP, ToolanDM, StecEM, Holder DJ, Soper KA, Heyse JF and Ferrer M. 2011. cSSMD: Assessing collective activity of multiple siRNAs in genome-scale RNAi screens. Bioinformatics27(20): 2775-2781 (doi: 10.1093/bioinformatics/BTR474).*listed among the 50 most-frequently cited articles in Bioinformaticssince 2013
  6. Zhang XHD. 2011. Illustration of SSMD, z-score, SSMD*, z*-score and t-statistic for hit selection in high-throughput screens. Journal of Biomolecular Screening16 (7): 775-785 (doi: 10.1177/1087057111405851)
  7. Zhang XHD, 2010. Contrast variable potentially providing a consistent interpretation to effect sizes. Journal of Biometrics & Biostatistics 1:108 (doi:10.4172/2155-6180.1000108)
  8. Zhang XHD, Lacson R, Yang R, Marine SD, McCampbell, Toolan DM, Hare TR, Kajdas J, Berger JP, Holder DJ, Heyse JF, Ferrer M. 2010. The use of SSMD-based false discovery and false non-discovery rates in genome-scale RNAi screens. Journal of Biomolecular Screening 15: 1123 – 1131 (doi: 10.1177/1087057110381919)
  9. Zhang XHD, 2010. An effective method controlling false discoveries and false non-discoveries in genome-scale RNAi screens. Journal of Biomolecular Screening 15: 1116 – 1122 (doi: 10.1177/1087057110381783)
  10. Zhao WQ, Santini F, Breese R, Ross D, Zhang XHD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ. 2010. Inhibition of calcineurin-mediated endocytosis and AMPA receptor prevent amyloid oligomer-induced synaptic disruption. Journal of Biological Chemistry285(10): 7619-7632 (doi:10.1074/jbc.M109.057182)
  11. Zhang XHD. 2010. Assessing the size of gene or RNAi effects in multi-factor high-throughput experiments. Pharmacogenomics 11(2): 199-213 (doi:10.2217/PGS.09.136)
  12. Zhang XHD. 2010. Strictly standardized mean difference, standardized mean difference and classical t-test for the comparison of two groups. Statistics in Biopharmaceutical Research 2(2) 292-299 (doi: 10.1198/sbr.2009.0074)
  13. Klinghoffer RA, Frazier J, Annis J, Berndt JD, Roberts BS, Arthur WT, Lacson R,Zhang XHD, Ferrer M, Moon, RT, Cleary MA. 2009. A lentivirus-mediated genetic screen identifies dihydrofolastereductase (DHFR) as a modulator of -actenin/GSK3 signaling. PLoS ONE 4(9): e6892 (doi:10.1371/journal.pone.0006892)
  14. Zhang XHD, Heyse JF. 2009. Determination of sample size for hit selection in genome-scale RNAi screens. Bioinformatics 25: 841-844 (doi:10.1093/bioinformatics/btp082)
  15. Zhang XHD, Shane SD, Ferrer M. 2009. Error rates and power in genome-scale RNAi screens. Journal of Biomolecular Screening 14:230-238 (doi:10.1177/1087057109331475)
  16. Zhang XHD. 2009. A method effectively comparing gene effects in multiple conditions in RNAi and expression profiling research.Pharmacogenomics10(3): 345-358 (doi:10.2217/14622416.10.3.345)
  17. Zhang XHD. 2008. Genome-wide screens for effective siRNAs through assessing the size of siRNA effects. BMC Research Notes 1:33 (doi:10.1186/1756-0500-1-33)
  18. Zhao WQ, Breese R, Wolfe AA, Ross DA, Santini F, Zhang XHD, Ferrer M, Stone D, Seabrook GR, Stulovici B, Kinney GG, Ray WJ, Shughrue PJ. 2008. Targeting synaptic AMPA receptors by oligomers.Alzheimer's & Dementia 4 (4):T197