基本情况

宋刚，博士，厦门大学医学院教授，硕士生导师。福建省高等学校新世纪优秀人才支持计划入选者；福建省细胞生物学学会理事；福建省生物工程学会理事；中国细胞生物学会等会员。在SCI收录期刊上发表论文20余篇，已被引用1000余次。主持国家自然科学基金面上项目、教育部部属高校教师科研业务费专项基金、福建省高等学校新世纪优秀人才支持计划项目（2011）、福建省科公益研院所专项基金及厦门市科技计划项目、厦门大学医学院人才引进启动基金等多项研究课题。

研究领域
目前主要从事“基于Bid、Osteopontin等分子靶点的消化道肿瘤发生发展过程中的信号转导机制、间充质干细胞（MSCs）对炎症性肿瘤的调控、DNA损伤检控点的调控与肿瘤的发生发展、抗肿瘤天然药物筛选及其作用机理等课题的研究


论文发表

  1. Li Y, Dai C, Li J, Wang W, Song G*. Bid-overexpression regulates proliferation and phosphorylation of Akt and MAPKs in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. OncoTargets and Therapy. 2012, 5: 279-286. (* Corresponding author)
  2. Hu C#, Song G#,*, Zhang B, Liu Z, Chen R, Hu TH*.Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway.J Cell Mol Med.2012, 16(1): 96-106. (# Co-first authors,* Co-Corresponding author)
  3. Huang JG, Xia C, Zheng XP, Yi TT, Wang XY, Song G, Zhang B.17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/AKT pathway. Cell Mol Biol Lett.2011, 16(4): 564-75
  4. Song G*, Wang WW, Hu Th.p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response.Medical Hypotheses,2011, 77(5): 850-852.(* Corresponding author)
  5. Ming YL, Chen ZY, Chen LH, Lin DJ, Tong QX, Zheng ZZ, Song G*.Ginsenoside compound K attenuated metastatic growth of hepatocellular carcinoma is associated with the translocation of Nuclear factor-кB p65 and reduction of matrix metalloproteinase2/9.Planta Medica, 2011, 77(5): 428-433. (* Corresponding author)
  6. Song G*, Guo S, Wang W, Hu C, Mao Y, Zhang B, Hu T*.Intestinal metabolite compound K of ginseng saponin potently attenuating metastatic growth of hepatocellular carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway.J Agric Food Chem. 2010, 58(24): 12753-60. (*Co-Corresponding author)
  7. Song G, Chen GG, Hu TH and Lai PBS.Bid Stands at the Crossroad of Stress-response Pathways.Current Cancer Drug Targets. 2010. 10 (6): 584-592
  8. Gang Song*, Shiguang Guo, Bing Zhang, and Tianhui Hu. Effects of Bid-Overexpression on Hepatocellular Carcinoma Cells Proliferation in Response to Etoposide-induced DNA Damage. Scientific and Technical Development Press, 2010, p407-411. (*Corresponding author)
  9. Song G, Ouyang G, Mao YB, Ming YL, Bao S, Hu TH. Osteopontin promotes metastatic growth of gastric cancer by augmenting cell survival and invasion through Akt-mediated HIF-1α up-regulation and MMP9 activation. J Cell Mol Med. 2009, 13(8B): 1706-1718
  10. Song G, Chen GG, Yun JP and Lai PBS.Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma. Current Cancer Drug Targets. 2009, 9(7): 871-880
  11. Song G, Cai QF, Mao YB, Ming YL, Bao S, Ouyang G. Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1α expression through the PI3-K/Akt pathway. Cancer Sci. 2008, 10: 1901-1907
  12. Song G, Ming Y, Mao Y, Bao S, Ouyang G. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via{alpha}v{beta}3 integrins in human gastric cancer cells. Exp Biol Med. 2008; 233(12): 1537-1545
  13. Song G, Chen GG, Chau DK, Miao J, Lai PBS. Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Apoptosis. 2008, 13(5): 693-701
  14. Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005, 9(1): 59-71
  15. Song G, Mao YB, Cai QF, Yao LM, Ouyang GL, Bao SD. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis via activating p53 and regulating apoptosis-related proteins. Braz J Med Biol Res. 2005, 38 (12): 1791-1798
  16. Ming YL, Song G, Chen LH, Zheng ZZ, Chen ZY, Ouyang G, Tong QX. Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol Int. 2007, 31:1265-1273
  17. Mao YB, Song G, Cai QF, Liu M, Luo HH, Shi MX, Ouyang GL, Bao SD. P53 involves in hydrogen peroxide-induced apoptosis in Human MGC803 cells. Cell Biol Int. 2006, 30: 332-337
  18. Ouyang G, Yao L, Ruan K, Song G, Mao Y, Bao S.Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol Int. 2009, 33(12): 1237-1244
  19. Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S.Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett. 2009, 281(2): 213-219
  20. Ruan K, Song G, Ouyang GL. Role of hypoxia in human cancer. Journal of Cellular Biochemistry. 2009, 107: 1053-1062
  21. 胡春，宋刚*，胡天惠*，人参皂苷肠道代谢物 Compound K抗肿瘤研究进展，肿瘤防治研究，2011，38（2）：221-223 (* Co-通讯作者)