基本情况

牛文彦，天津医科大学教授、博士研究生导师。

 

研究领域

1.肥胖和糖尿病相关的胰岛素抵抗研究

2.免疫细胞在慢性炎症中作用的研究

3.细胞信号转导

 

主要经历

2009年晋升为教授

2004年晋升为副教授

1999年加拿大多伦多病童医院访问学者

1989年晋升为讲师

 

论文发表

  1. Sweeney G, Niu W, Kanani R, Klip A. Regulation of the Na,K-pump by leptin in 3T3-L1 fibroblasts. Endocrinology. 2000 Mar, 141 (3): 1277-1280.
  2. Somwar R, Niu W, Kim DY, Sweeney G, Randhawa VK, Huang C, Ramlal T, Klip A. Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport. J. Biol. Chem. 2001 Dec, 276 (49): 46079-46087.
  3. Sweeney G, Niu W, Canfield VA, Levenson R, Klip A. Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells. Am J Physiol Cell Physiol. 2001 Dec, 281 (6): C1797-1803.
  4. Somwar R, Kim DY, Sweeney G, Huang C, Niu W, Lador C, Ramlal T, Klip A. GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem. J. 2001 Nov, 359: 639-649.
  5. Huang C, Somwar R, Patel N, Niu W, Torok D, Klip A. Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes. 2002 Jul, 51 (7): 2090-2098.
  6. Konrad D, Bilan PJ, Nawaz Z, Sweeney G, Niu W, Liu Z, Antonescu CN, Rudich A, Klip A. Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes. 2002 Sep, 51 (9): 2719-2726.
  7. Furtado LM, Somwar R, Sweeney G, Niu W, Klip A. Activation of the glucose transporter GLUT4 by insulin. Biochem. Cell Bio. 2002; 80:569-578.
  8. Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A. Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. J. Biol. Chem. 2003 May, 278 (20): 17953-17962.
  9. Rudich A, Konrad D, Torok D, Ben-Romano R, Huang C, Niu W, Garg RR, Wijesekara N, Germinario RJ, Bilan PJ, Klip A. Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues. Diabetologia. 2003 May, 46 (5): 649-658.
  10. Antonescu CN, Huang C, Niu W, Liu Z, Eyers PA, Heidenreich KA, Bilan PJ, Klip A. Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity. Endocrinology. 2005 Sep, 146 (9): 3773-3781.
  11. Antonescu CN, Thong F, Niu W, Karnieli E, Klip A. To be or not to be: Regulation of the intrinsic activity of GLUT4. Curr. Med. Chem- Immun.. 2005; 5:175-187.
  12. Wang Y, Yang J, Gao Y, Du Y, Bao L, Niu W, Yao Z. Regulatory effect of e2, IL-6 and IL-8 on the growth of epithelial ovarian cancer cells. Cellular Mol. Immun. 2005 Oct, 2 (5): 365-372.
  13. JeBaily L, Wanono O, Niu W, Roessler J, Rudich A and Klip A. Ceramide- and oxidant-induced insulin resistance involves loss of insulin-dependent rac-activation and actin remodling in muscle cells. Diabetes. 2007 Sep; 56:394-403.
  14. NIU Wenyan, Manabu Ishiki, Philip J Bilan and YAO Zhi. Glucose transporter 4 can insert in the membrane without exposing its catalytic site for photolabeling from the medium. Science in China Series-C: Life Sciences. 2007 Apr; 50(2):147-154.
  15. NIU Wenyan, Philip J Bilan, Michiko Hayashi, DA Yurong, YAO Zhi, Insulin sensitivity and inhibition by forskolin, dipyridamole and pentobarbital of glucose transport in three L6 muscle cell lines. Science in China Series-C: Life Sciences. 2007 Dec; 50(6):739-747.
  16. Y Zhang, Y-L Wang, Y-W Liu, R-F Han, Q Li, W-Y Niu, Y-J Song, L-Y Sun, Z-J Zhu, Z-Y Shen. Change of Peripheral Blood Mononuclear Cells IFN- IL-10 and TGF-1 mRNA Expression Levels with Active Human Cytomegalovirus Infection in Orthotopic Liver Transplantation. Transplantation Proc, 2009; 41(5):1767-9.
  17. Yuliang Wang, Yawu Liu, Ruifa Han, Qiang Li, Zhi Yao, Wenyan Niu, Yuhua Yuan, Zhiqin Tang, Zhijun Zhu and Zhongyang Shen. Monitoring of CD95 and CD38 expression in peripheral blood T lymphocytes during active human cytomegalovirus infection after orthotopic liver transplantation. Journal of Gastroenterology and Hepatology. 2010 Jan; 25:138-142.
  18. Niu W, Bilan P J, Ishikura S, Schertzer J D, Contreras-Ferrat A, Fu Z, Liu J, Boguslavsky S, Foley K P, Liu Z, Li J, Chu G, Panakkezhum T, Lopaschuk G D, Lavandero S, Yao Z, Klip A. Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells. Am. J. Physiol. Endocrinol. Metab., 2010 May;298(5):E1058-71.
  19. Niu W, Bilan PJ, Yu J, Gao J, Boguslavsky S, Schertzer JD, Chu G, Yao Z. PKCe regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells. Journal of Cellular Physiology. 2011 Jan;226(1):173-80.
  20. Shi L, Qin N, Hu L, Liu L, Duan H, Niu W. Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells. Diabetes Research and Clinical Practice. 2011 May;92(2):e41-6.
  21. Yu J, Shi L, Wang H, Bilan PJ, Yao Z, Samaan MC, He Q, Klip A, Niu W. Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant. European Journal of Cell Biology. 2011 Dec;90:1000-1015.
  22. Qin N, Li C, Jin M, Shi L, Duan H, Niu W.. Synthesis and biological activity of novel tiliroside derivants. European Journal of Medicinal Chemistry. 2011 Oct;46:5189-5195.
  23. Hong W, Li J, Wang B, Chen L, Niu W, Yao Z, Baniahmad A. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011 Dec 2;415(4):650-655.
  24. Xiaolei Liu, Hairui Yuan, Yanmei Niu, Wenyan Niu, Li Fu. The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal mucle of C57BL/6 mice. BBA-Molecular Basis of Disease. Biochim Biophys Acta. 2012 Nov;1822(11):1716-26.
  25. Xin Z, Liu C, Niu WY, Feng JP, Zhao L, Ma YH, Lin H, Yang JK. Identifying obesity indicators which best correlate with type 2 diabetes in a Chinese population. BMC Public Health. 2012 Sep 1;12(1):732.
  26. Zhou JB, Liu C, Niu WY, Xin Z, Yu M, Feng JP, Yang JK. Contributions of Renin-Angiotensin system-related gene interactions to obesity in a chinese population. PLoS One. 2012;7(8):e42881.
  27. Cesar Osorio-Fuentealba, Ariel E. Contreras-Ferrat, Francisco Altamirano, Alejandra Espinosa, Qing Li, Wenyan Niu, Sergio Lavandero, Amira Klip, Enrique Jaimovich. Electrical Stimuli Release ATP to Increase Glucose Uptake and GLUT4 Translocation via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells. Diabetes. 2013 May;62(5):1519-26
  28. Hairui Yuan, Yanmei Niu, Xiaolei Liu, Fengying Yang, Wenyan Niu and Li Fu. Proteomic analysis of skeletal muscle in insulin-resistant mice: Response to 6-week aerobic exercise. PLoS One, 2013;8(1):e53887.