基本情况

王志华，医学博士，华中科技大学同济医学院附属同济医院，主要从事泌尿外科临床和科研工作，师从世界著名前列腺癌专家（“PSA之父”）CATALONA教授。目前担任学术职务：美国泌尿外科学会（AUA）会员，欧洲泌尿外科学会（EUA）会员，世界腔道泌尿外科学会（WCE）会员，世界泌尿肿瘤联盟（WUOF）会员，中华医学会泌尿外科学分会湖北省青年委员，《现代泌尿生殖肿瘤杂志》主编助理及编委，《汉斯外科学》杂志编委。并担任《Molecular Biology Reports》、《Oncology Letter》、《国际临床报告》、《中华实验外科杂志》、《中华外科杂志》、《肿瘤防治研究》、《临床泌尿外科杂志》等杂志审稿人。

 

研究方向

泌尿系肿瘤的基础与临床

 

论文发表

  1. Wang Zhihua, Zhou Chun, Ye Qing, et al. Gene Construction and Protein 3D model of anti-PAF ScFv Antibody. Journal of Huazhong University of Science and Technology (Nature Sciences). 2004, 32(6): 114-116
  2. Ye Qing, Wang Zhihua, Wang shuo, et al. Activation Lymphocytes by anti-CD71 mouse/human chimeric antibody in vitro. Chinese Journal of Microbiology and Immunology.2004,24(7)509-513
  3. Ye Qing, Wang Zhihua, Zhen Hongyan, et al. Construction and Detection of the Mice Model for Graft Versus Host Disease. Journal of Huazhong University of Science and Technology (Medicine Sciences). 2004，33(6):651-654
  4. Yang DF, Zhu HF, Wang ZH, et al. Construction of single chain Fv antibody against transferrin receptor and its protein fusion with alkaline phosphatase. World J Gastroenterol 2005;11(21):3300-3303
  5. Wang Zhihua, Ye Qing, Ye Zhangqun, et al.In vitro Anti-tumor Effect of CTL Induced by Hsp70-Id Complex-modified DC. Chinese Journal of Oncology, 2006, 28(6): 481-485
  6. Qing Y, Shuo W, Zhihua W, et al. The in vitro antitumor effect and in vivo tumor-specificity distribution of human-mouse chimeric antibody against transferrin receptor. Cancer Immunol Immunother. 2006,55(9):1111-1121 (SCI, IF:4.319)
  7. ZHU LJ, LIAO W, ZHU HF, LEI P, WANG ZH, SHEN GX. Construction, Expression and In Vitro Biological Behaviors of Ig scFv Fragment in Patients with Chronic B Cell Leukemia. Journal of Huazhong University of Science and Technology [Med Sci ].2006, 26 (2):157-160
  8. Wang Zhihua, Hu Zhiquan,Ye Zhangqun, et al .Antisense RNA of survivin gene enhance taxol-induced apoptosis in bladder cell line BIU87.Chinese Medicine Journal, 2007, 87(6): 419-424
  9. Shen X, Zhu HF, He FR, Wang ZH, Shen GX.An anti-transferrin receptor antibody enhanced the growth inhibitory effects of chemotherapeutic drugs on human non-hematopoietic tumor cells.Int Immunopharmacol. 2008 Dec 20;8(13-14):1813-20. (SCI, IF:2.157)
  10. Liu J, Xiao D, Wang ZH, et al. Preparation and identification of scFv and bsFv against transferrin receptor. J Huazhong Univ Sci Technolog [Med Sci ].2008 Dec;28(6):621-5
  11. YE Qing, WANG Zhi-Hua, QIN Shu-Kui, et al. Preparation of Heat Shock Protein 70 (Hsp70) and Idiotypic Determinant Single-chain Antibody (Id-ScFv) in a Patien with B-cell Chronic Lymphatic Leukemia (B-CLL) and Antitumor Effect of Peptide Complex Hsp70-Id. Chinese Oncology Research. 2008; 27(2):133-8
  12. Chen XG, Liu F, Song XF, Wang ZH, Zhuang QY,et al.  Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways [J]. Mol Carcinog. 2010 Jun; 49(6):603-10.(IF3.6)
  13. Qing Ye, Zhihua Wang,  Yanshu Li, et al.The effect of anti-TfR mouse/human chimeric antibody on Anti-Transplant rejection. Transpl Int. 2011 Feb;24(2):167-74..（共同第一作者) (IF3.2)
  14. LIU Shuanglin,WANG Zhihua, HU Zhiquan, et al.Curcumin exerts anti-tumor activity in androgen independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro. J Huazhong Univ Sci Technolog [Med Sci ].2011 ,31(4):530-534
  15. WANG Zhi-hua, LI You-yuan, HU Zhi-quan, ZHU Hui, ZHUANG Qian-yuan, QI Yong , YE Zhang-qun. Does urothelial cancer of bladder behave differently in young patients? Chinese Medical Journal, Chin Med J (Engl). 2012 Aug; 125(15):2643-8
  16. Wang Z, Lu T, Du L, Hu Z, Zhuang Q, Li Y, Wang CY, Zhu H, Ye Z. Plasmacytoid urothelial carcinoma of the urinary bladder: a clinical pathological study and literature review. Int J Clin Exp Pathol. 2012;5(6):601-8
  17. Zhang S, Lv JW, Yang P, Yu Q, Pang J, Wang Z, Guo H, Liu S, Hu J, Li J, Leng J, Huang Y, Ye Z, Wang CY. Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling. Am J Pathol. 2012 Sep;181(3):937-46
  18. Wang Q, Shu R, He H, Wang L, Ma Y, Zhu H, Wang Z, Wang S, Shen G. Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference. Int J Oncol. 2012 Aug;41(2):652-60
  19. Li Y, Zhuang Q, Hu Z, Wang Z, Zhu H, Ye Z. A modified ureteroileal anastomosis technique for Bricker urinary diversion. Urology. 2011 Nov;78(5):1191-5
  20. Qing Ye, Heyu Hu, Zhihua Wang, Tong Lu, Zhiquan Hu, Xing Zeng, Shu Zhang, Jing Liu, Ping Lei, Cong-Yi Wang, Zhangqun Ye and Guanxin ShenGeneration and functional characterization of the anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4) fusion protein. BMC Biotechnology. 2012, 12:91. (通讯作者)


主持部分课题

1.   国家自然基金1项（主持）：免疫纳米载体靶向介导SaRNA激活LKF4抗前列腺癌实验研究(NO.81101944)）

2.   教育部新青年教师基金1项（主持）：新型免疫纳米载体靶向膀胱癌激活P21基因抗肿瘤效应研究(No.20090142120096)

3.   湖北省自然基金1项（主持）：免疫纳米载体KLF4-SaRNA靶向前列腺癌的生物学效应研究(No.2011CDB202)

4.   华科大自主创新专项基金1项（主持）：新型免疫纳米载体KLF4-SaRNA靶向前列腺癌的体内效应及其成像研究（NO.2001JC038）

5.   教学课题华中科技大学教改项目1项（主持）：外科学E-learning教学平台的构建