基本情况

罗元明，博士，研究员级高级工程师，中国科学院“现有关键技术人才计划”获得者，中国科学院评审专家（工程技术类），中国质谱学会网络研讨会学术委员。2004年毕业于中国协和医科大学生物化学与分子生物学专业博士学位，现任中科院微生物研究所公共技术服务中心主任，质谱与功能组学实验室负责人，微生物所技术条件委员会委员，修购工作组副组长。

 

研究领域

糖蛋白质组学、修饰组学及临床质谱在精准医学领域的应用开发

 

教育背景

2012.01-2012.04 高级访问学者，奥地利BOKU大学

2001.09-2004.07 博士，中国协和医科大学

1998.09-2001.07 硕士，吉林大学

1992.09-1996.07 学士，重庆师范大学

 

科研成就

主持及参与了13项省部级及以上课题，在Mol cell Proteomcis、J Proteome Res、Proteomics等蛋白组学权威杂志上发表了40多篇SCI论文。主持建立了基于生物质谱的20多套技术体系和研究方案，具体包括蛋白及PTM鉴定、比较蛋白组学、定量蛋白组学、代谢组学、仿制药的生物等效性分析及抗体药的质量控制技术（糖型、含量、杂质、肽谱、糖谱及二硫键等分析技术）等，广泛应用于疾病机理研究、药物研发、药物质量控制、重大疾病的临床筛查和辅助诊断、药物检测标准的建立及诊断试剂盒的研制等。

 

论文发表

  1. Wang FX, Luo YM, Ye ZQ, Cao X, Liang JN, Wang Q, Wu Y, Wu JH, Wang HY, ZhangM, Cheng HQ, Xia GX. iTRAQ-based proteomics analysis of autophagy-mediated immune responses against the vascular fungal pathogen Verticillium dahliae in Arabidopsis. Autophagy, 2018, 14(4): 598-618.
  2. Cao J, Yang C, Li L, Jiang L, Wu Y, Wu C, Bu Q, Xia G, Liu X, Luo Y*, Liu J. Rice Plasma Membrane Proteomics Reveals Magnaporthe oryzae Promotes Susceptibility by Sequential Activation of Host Hormone Signaling Pathways. Mol Plant Microbe Interact. 2016, 29(11): 902-913.
  3. Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, Wang J, Luo Y, Wang Q, Luo T, Jiang Y. mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. Cell Res. 2016, 26(1): 46-65.
  4. Liu H#, Luo Y#, Han J, Wu J, Wu Z, Feng D, Cai S, Li M, Liu J, Zhou J, Xiang H. Proteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations. J Proteome Res, 2013, 12(3): 1300-1315 (#shared first author).
  5. Sun L, Chen L, Sun L, Pan J, Yu L, Han L, Yang Z, Luo Y*, Ran Y*. Functional screen for secreted proteins by monoclonal antibody library and identification of Mac-2 binding protein as a potential therapeutic target and biomarker for lung cancer. Mol Cell Proteomics, 2013, 12(2): 395-406 (*corresponding author).
  6. Yu T, Xu X, Peng Y, Luo Y*, Yang K*. Cell wall proteome of Clostridium thermocellum and detection of glycoproteins. Microbiol Res, 2012, 167: 364-371 (*corresponding author).
  7. Sun Q, Liu X, Wang Q, Luo Y*, Wang X*. Protein expression pattern identifies morphological variability of ascomatal hairs in the two species of genus Chaetomium. Acta Microbiologica Sinica, 2012, 52(10): 1203-1209 (*corresponding author).
  8. Wang FX, Ma YY, Yang CL, Zhao PM, Yao Y, Jian GL, Luo YM*, Xia GX*. Proteomic analysis of the sea-island cotton roots infected by wilt pathogen verticillium dahlia. Proteomics, 2011, 11, 4296-4309 (*corresponding author).
  9. Yu T#, Luo Y#, Yang K. Rapid characterization of N-linked glycosylation site using non-specific protease digestion of gel-separated glycoproteins and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry. Eur J Mass Spectrom, 2011, 17(6): 573-579 (#shared first author).
  10. Zhao PM, Wang LL, Han LB, Wang J, Yao Y, Wang HY, Du XM, Luo YM*, Xia GX*. Proteomic identification of differentially expressed proteins in the Ligon lintless mutant of upland cotton (Gossypium hirsutum L.). J Proteome Res, 2010, 9(2): 1076-1087 (*corresponding author).
  11. Mao S#, Luo Y#, Zhang T, Li J, Zhang Y, Ma Y, Li Y. Proteome reference map and comparative proteome analysis between a wild type Clostridium acetobutylicum DSM 1731 and its mutant with enhanced butanol tolerance and butanol yield. J Proteome Res, 2010, 9(6): 3046-3061(#shared first author).
  12. Ouyang H, Luo Y*, Zhang L, Li Y, Jin C*. Proteome analysis of Aspergillus fumigatus total membrane proteins identifies proteins associated with the glycoconjugates and cell wall biosynthesis using 2D LC-MS/MS. Mol Biotechnol, 2010, 44(3): 177-189 (*corresponding author).
  13. Luo Y, Li Y, Lin C, Ma H, Zhang J, Wu S, Wang X, Gao Y, Liu Y, Zheng D. Comparative proteome analysis of splenic lymphocytes in senescence-accelerated mice. Gerontol, 2009, 55(5): 559-569.
  14. Chen G#, Luo Y#, Wang X, Zhao Z, Liu H, Zhang H, Li Z. A relatively simple and economical protocol for proteomic analyses of human 20S Proteasome: compatible with both scaled-up and scaled-down purifications. Electrophoresis, 2009, 30: 2422-2430 (#shared first author).