基本情况

许文涛，1979年出生，中国农业大学，食品科学与营养工程学院食品营养与安全系，副教授，博士生导师。荣获教育部新世纪优秀人才，北京市科技新星；转基因生物安全协同创新中心新性状转基因生物食用安全检测与评价技术平台岗位科学家；农业部农产品贮运保鲜质量安全风险评估实验室（北京），副主任及岗位科学家；国家无公害食品评审委员会委员；农业部转基因生物食用安全监督检验测试中心（北京），主任助理兼分子检测室主任；农业部农产品质量安全监督检验测试中心（北京），主任助理兼微生物检测室主任。1997年至2001年，中国农业大学食品科学与营养工程学院营养与生物工程系获得学士学位；2001年至2006年，中国农业大学食品科学与营养工程学院食品营养与安全系获得博士学位；2013年至2014年，美国马里兰大学，营养与食品科学系，访问学者。

 

研究领域

长期从事“生物源风险因子检测与毒理评价”领域的研究工作，在生物毒素检测及致毒机制，转基因食品检测与安全评价，食品安全快速检测技术，食品微生物控制及检测技术4个食品安全领域开展工作。

 

论文发表

在食品安全领域已经发表已发表论文200余篇，其中SCI收录100余篇，参与获得国家级教学成果奖1项、省部科技二等奖3项、三等奖2项。省部级成果鉴定10项，申请专利20余项，获得授权国家专利16余项。主编和参编教材10部包括《转基因食品安全评价与检测技术》（主编），《食品安全案例解析》（主编），《转基因食品社会文化伦理透视》（主编），《食品营养与安全》（主编），《转基因食品》（主编），《国际转基因生物食用安全检测及其标准化》（副主编），《食品安全检测技术》（参编），和《食品生物技术实验指导》（参编）等。

  1. An advanced visual qualitative and EVA Green-based quantitative isothermal amplification method to detect Listeria monocytogenes, Journal of Food Safety. 2015, In press, N. Cheng, Y. Xu, X. Yan, Y. Shang, P. Zhu, W. Tian, Z. Liang, W Xu*
  2. Lipid rafts disruption increases ochratoxin A cytotoxicity to hepatocytes, Journal of Biochemical and Molecular Toxicology, 2015, In press, Y. Zhang, X. Qi, J. Zheng, Y. Luo, C. Zhao, J. Hao, X Li, K. Huang, W. Xu*
  3. High-throughput tag-sequencing Analysis of Early Events Induced by Ochratoxin A in HepG-2 cells Journal of Biochemical and Molecular Toxicology, 2015, In press, Y. Zhang, X. Qi, J. Zheng, Y. Luo, K. Huang, W. Xu*
  4. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells Scientific reports, 2015, In press, Y. Li, X. He , X. Yang, K. Huang, Y. Luo, L. Zhu, Y. Li, W. Xu*
  5. A highly sensitive and specific method for the screening detection of genetically modified organisms based on digital PCR without pretreatment, Scientific reports, 2015, 5. P Zhu, W Fu, C Wang, K Huang, Z Du, W Tian, Q Wang, H Wang, W. Xu*, S Zhu.
  6. Arabidopsis thaliana defense response to the ochratoxin A-producing strain (Aspergillus ochraceus 3.4412), Plant Cell Reports, 2015, 34(5): 705-719. J. Hao,W. Wu, Y. Wang, Z. Yang, Y. Liu, Y. Lv, Y. Zhai, J, Yang, Z. Liang, K. Huang, W. Xu*
  7. Effect of ochartoxin A and buthionine sulfoximine on proteome and ascorbate-glutathione cycle enzymes in Arabidopsis thaliana, Biologia Plantarum, 2015, 59(2), 331-340. J. Hao, Y. Wang, W. Zhao, W. Xu*, Y. Luo, Z. Yang, W. Wu, Z. Liang, K. Huang
  8. Red Ginseng and Semen Coicis can improve the structure of gut microbiota and relieve the symptoms of ulcerative colitis. Journal of Ethnopharmacology. 2015, 162, 7-13. M. Guo, S. Ding, C. Zhao, X. Gu, X. He, K. Huang, Y. Luo, Z. Liang, H. Tian, W. Xu*
  9. Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity. Scientific reports. 2015,5: 8078. R. Liang, X.L. Shen, B. Zhang, Y. Li, W. Xu*, C. Zhao, Y. Luo, K. Huang
  10. A Review of Test strips in Rapid Detection of Food Safety,  Austin J Nutri Food. 2014, 2(7): 6. N. Cheng, L. Zhu, Y. Xu, W. Xu*
  11. Proteomics as an Indicator for the Research of Cell Apoptpsis in Toxicology. Austin J Peotecmics, Bioinformatics & Genomics. 2014, 1(1): 6. X. Yang, W. Xu*
  12. Dynamic changes of global DNA methylation and hypermethylation of cell adhesion-related genes in rat kidneys in response to ochratoxin A. World Mycotoxin Journal. 2015, 8(4): 465–476. X. Li, J. Gao, K. Huang, X. Qi, Q. Dai, X. Mei, W. Xu*
  13. Safety assessment of genetically modified rice expressing human serum albumin from urine metabonomics and fecal bacterial profile. Food Chem. Toxicol. 2015, 76: 1-10. X. Qi, S. Chen, Y. Sheng, M. Guo, Y. Liu, X. He, K. Huang, W. Xu*
  14. A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats. Transgenic Research. 2015, 24(2): 295-308. H. Song, X. He, S. Zou, T. Zhang, Y. Luo, K. Huang, Z. Zhu, W Xu*
  15. Ochratoxin A induces rat renal carcinogenicity with limited induction of oxidative stress responses. Toxicology and applied pharmacology. 2014, 280(3): 543–549. X. Qi, S. Chen, Y. Sheng, M. Guo, Y. Liu, X. He, K. Huang, W. Xu*
  16. Toxicological evaluation of lactase derived from recombinant Pichia pastoris. Plos One. 2014, 9(9): 106470. S. Zou, X. Hea, Y. Liu, D. Chen, Y. Luo, K. Huang, W. Zhang, W. Xu*
  17. Discovery of systematic responses and potential biomarkers induced by Ochratoxin A using metabolomics. Food Additives and Contaminants Part A, 2014, 31(11): 1904-13. K. Xia; X. He; Q. Dai; W.H. Cheng; X. Qi; M. Guo; Y. Luo; K. Huang; C. Zhao; W. Xu*;
  18. A-T linker adapter polymerase chain reaction for determining flanking sequences by rescuing inverse PCR or thermal asymmetric interlaced PCR products. Analytical biochemistry. 2014, 466C: 24-26. Q. Trinh; P. Zhu; H. Shi; W. Xu*; J. Hao; Y. Luo; K. Huang
  19. Mitochondrial proteomic analysis reveals the molecular mechanisms underlying reproductive toxicity of zearalenone in MLTC-1 cells Toxicology. 2014, 141(1): 314-323. Y. Li, B Zhang, K. Huang, X. He, Y. Luo, R. Liang, H. Luo, X.L. Shen, W. Xu*
  20. Combination of metagenomics and culture based methods to study the interaction between ochratoxin A and gut microbiota. Toxicological Sciences. 2014, 141(1): 314-323. M. Guo, K. Huang, S.Chen, X. Qi, X. He, W.H. Cheng, Y. Luo, K. Xia, W. Xu*
  21. Subchronic toxicity study in vivo and allergenicity study in vitro for genetically modified rice that expresses pharmaceutical protein (human serum albumin). Food Chem. Toxicol. 2014, 72: 242-246. Y. Sheng, X. Qi, Y. Liu, M. Guo, S. Chen, X. He, K. Huang, W. Xu*
  22. Ochratoxin A induced early hepatotoxicity: new mechanistic insights from microRNA, mRNA and proteomic profiling studies. Scientific reports. 2014, 4: 5163. X.Z Qi, X. Yang, S.Y. Chen, X.Y. He, H. Dweep, M.Z. Guo, W.H. Cheng, W.T. Xu*, Y.B. Luo, N. Gretz, Q. Dai, K.L. Huang
  23. DNA damage and S phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK 293). Mutat Res-Fund Mol M. 2014, 765: 22-31. Q. Yang, X.Y. He, X.H. Li, W.T. Xu*, Y.B. Luo, X. Yang, Y. Wang, Y.C. Li, K.L. Huang
  24. microRNA profilingof rats with ochratoxin A nephrotoxicity. BMC Genomics. 2014, 15: 333. Q. Dai, J. Zhao, X.Z. Qi, W.T. Xu*, X.Y He, M.Z. Guo, H. Dweep, W.H. Cheng, Y.B. Luo, K. Xia, N. Gretz, K.L. Huang
  25. Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK-293). Food Chem. Toxicol. 2014, 70: 40-47. Q. Yang, L. Shi, K.L. Huang, W.T. Xu*
  26. Development and Application of a Quantitative Loop mediated Isothermal Amplification Method for Detecting Genetically Modified Maize MON863. J. Sci. Food Agric.2014, DOI: 10.1002/jsfa.6707. S.C. Huang, Y.C Xu, X.H. Yan, Y. Shang, P.Y. Zhu , W.Y. Tian , W.T. Xu*
  27. Central role of Nix in the autophagic response to orchratoxin A Food Chem. Toxicol. 2014, 69: 202-209. X.L. Shen, B.Y. Zhang, R. Liang, W.H. Cheng, W.T. Xu*, Y.B. Luo, C.H. Zhao, K.L. Huang
  28. Analysis of Individual and Combined Effects of Ochratoxin A and Zearalenone on HepG2 and KK-1 Cells with Mathematical Models. Toxins. 2014, 6(4): 1177-1192. Y.Z. Li, B.Y. Zhang, X.Y. He, W.H. Cheng, W.T. Xu*, Y.B. Luo, R. Liang , H.S. Luo, K.L. Huang
  29. Protective role of the mitochondrial Lon protease 1 in ochratoxin A-induced cytotoxicity in HEK293 cells. Journal of Proteomics. 2014,101:154-68. B.Y. Zhang, X.L. Shen, R. Liang, Y.Z. Li, K.L. Huang, C.H. Zhao, Y.B. Luo, W.T. Xu*
  30. Restriction enzyme cutting site distribution regularity for DNA looping technology Gene. 2014, 534(2): 222-228. Y. Shang, N. Zhang, P.Y. Zhu, Y.B. Luo, K.L. Huang, W.Y. Tian, W.T. Xu*
  31. A peach (Prunuspersica)-specific gene, Lhcb2, used as an endogenous reference gene for qualitative and real-time quantitative PCR to detect fruit products. LWT-Food Science and Technology. 2014, 55(1): 218-223 Y Shang, P Zhu, K Huang, W Liu, W Tian, Y Luo, W.T. Xu*
  32. Randomly broken fragment PCR with 5’ end-directed adaptor for genome walking. Scientific reports. 2013, 3: 3465. W.T. Xu, Y. Shang, P.Y. Zhu, Z.F. Zhai, J.He, K.L. Huang, Y.L. Luo
  33. An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK 293 cells. Journal of Proteomics. 2013, 78(14): 398-415. X.L. Shen, Y. Zhang, W.T. Xu*, R. Liang, J.J. Zheng, Y.B. Luo, Y. Wang, K.L. Huang
  34. Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A. Toxicol Appl Pharm. 2013, 268(2): 123-131. J Zheng, Y Zhang, W.T. Xu*, YB Luo, J Hao, X Shen, X Yang, X Li, K Huang
  35. Comparative proteomics and physiological characterization of Arabidopsis thaliana seedlings in responses to Ochratoxin A. Plant molecular biology. 2013, 82(4-5): 321-337. Y Wang, J Hao, W Zhao, Z Yang, W Wu, Y Zhang, W.T. Xu*, YB Luo, K Huang
  36. A 90-day feeding study of glyphosate-tolerant maize with the G2-aroA gene in Sprague–Dawley rats. Food Chem. Toxicol. 2013, 51: 280-287. Y Zhu, X He, Y, S Zou,X Zhou, KHuang, W Xu*
  37. Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement. Scientific reports. 2013, 3: 1962. Y Yuan, W Xu*, X He, H Liu, S Cao, X Qi, K Huang, Y Luo
  38. The transcriptional response of virulence genes in Listeria monocytogenes during inactivation by nisin. Food Control. 2013, 31(2): 519–524. H Shi,Q Trinh, W Xu*, Y Luo, W Tian, K Huang
  39. Development and optimization of an efficient method to detect the authenticity of edible oils. Food Control. 2013, 31(1): 71-79. J He, W Xu*, Y Shang, P Zhu, X Mei, W Tian, K Huang
  40. Single universal primer multiplex ligation-dependent probe amplification with sequencing gel electrophoresis analysis. Analytical Biochemistry. 2013, 443(2): 243-248. Y Shang, P Zhu, W Xu*, T Guo, W Tian, Y Luo, K Huang
  41. Restriction enzyme cutting site distribution regularity for DNA looping technology. Gene. 2013, 534(2): 222-8.Y Shang, N Zhang, P Zhu, Y Luo, K Huang, W Tian, W Xu*