基本情况

周宇涵，博士，大连理工大学，制药科学与技术学院，教授，博士生导师。

 

研究领域

药物合成化学等

 

教育经历

2009年2月至2010年1月 博士后，法国巴黎第五大学药学院

2000年3月至2003年2月 博士，大连理工大学精细化工系

1997年9月至2000年3月 硕士，大连理工大学精细化工系

1993年9月至1997年7月 学士，大连理工大学精细化工系

 

论文发表

  1. Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent azidation of trifluoromethyl alkenyl triflates: transition-metal-free Access to CF3-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5), 2858-2868
  2. Yuhan Zhou,* Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao, Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222
  3. Dong Li, Yuhan Zhou,* Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J. Fluorine Chem. 2018, 212, 122-129
  4. Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang, Jingping Qu. Iron-catalyzed boration of allylic alcohols with H3BO3 as an additive. Synth. Commun. 2018, 48(7), 795-801
  5. Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of gem-difluoroallylboronates via FeCl2-catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949
  6. Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585
  7. Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org. Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles)
  8. Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14
  9. Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of 6-trichloromethylphenanthridines by transition metal-free radical cyclization of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208
  10. Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org. Chem. 2016, 81(11), 4797-4806
  11. Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping Qu*. Highly selective fluorescence sensors for the fluoride anion based on carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back cover)
  12. Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols. ARKIVOC 2016, (iii), 110-124
  13. Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl2-catalyzed hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713
  14. Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44, 14952-14958
  15. Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe3+ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67
  16. Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones.J. Fluorine Chem. 2015, 173, 6-11
  17. Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109
  18. Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77
  19. Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674
  20. Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520
  21. 杨冬梅，周宇涵，* 常晴，赵一龙，曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986
  22. Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259
  23. Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of trifluoromethyl ketones via tandem claisen condensation and retro-claisen C−C bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)
  24. Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(µ-SeMe)3FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182
  25. Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912
  26. Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic. Nature Chem. 2013, 5(4), 320-326
  27. Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087
  28. 徐珊珊，周宇涵*，曲景平*. CuOTf/NNN三齿钳形配体催化不对称Henry反应. 有机化学, 2012, 32(7), 1131-1135
  29. Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction by LiCl-assisted BINOL―titanium species，Org. Lett. 2012, 14, 2734-2737
  30. 董晓亮，周宇涵*，徐珊珊，曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026
  31. 赵金凤，窦海建，周宇涵，曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报，2011, 32 (10), 2331-2334
  32. Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704)
  33. Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem. Res.2010, 34(12), 684-688
  34. Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 （Synfacts 2010, 6, 1266）
  35. Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316
  36. Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly efficient and regioselective allylic amination of allylic alcohols catalyzed by [Mo3PdS4] cluster. Tetrahedron Lett. 2010, 51, 1982-1984
  37. Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.* Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010)
  38. Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663


授权专利

  1. 周宇涵，曲景平，杨冬梅，薛娜. 一种制备全氟烷基烷基酮化合物的方法. 专利号：201210411390.2，2015-2-25
  2. 宋伟国，周宇涵，付永强，董良军，徐文方. 一种拉唑类化合物单一对映体的分离方法. 专利号：201310118349.0，2015-6-17
  3. 宋伟国，付永强，孙晓明，董良军，高东圣，周宇涵，夏艳，王伟，吕伟香，田梅. 一种用于埃索美拉唑不对称合成的催化剂. 专利号: 201410286767.5, 2016.7.6
  4. 周宇涵，曲景平，董晓亮. 一类以蒽为母体的双功能荧光探针、制备方法及应用. 专利号: 201510181059.X, 2016.12.7
  5. 周宇涵，曲景平，柳阳，王欢.基于铁催化制备烷基硼酸酯化合物的方法.专利号:201510292951.5, 2017.6.27
  6. 周宇涵，曲景平，董晓亮. 一类羧酸根桥联双核铁配合物荧光探针、制备方法及应用. 专利号: 201510561049.9, 2017.10.24
  7. 周宇涵，曲景平，柳阳，赵一龙. 一种二氟烯丙基硼酸酯的制备方法及其应用. 专利号: 201610635012.0, 2018.3.13
  8. 董良军，周宇涵，高东圣，王福洲，褚亚飞，吕伟香，李书涛，杨磊，宋伟国. 一种适用于工业化生产的右兰索拉唑的处理方法. 专利号：201510964214.5，2017.11.28
  9. 周宇涵，曲景平，吴昌朋，董晓亮. 一类6-三氯甲基菲啶类化合物及其制备方法和应用. 专利号：ZL 201610294227.0，2018.7.13
  10. Yuhan Zhou, Jingping Qu,  Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. JP 2017-558380, 2018.12.14


专著

  1. Yuhan Zhou, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12)
  2. Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Košmrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232
  3. 李和平，周宇涵，冯光柱，申艳敏，黄雪，刘云，袁超，何利霞. 含氟溴碘精细化学品. 北京：化学工业出版社，2010-09-01.（“十一五国家重点图书”）
  4. 李和平，冯光柱，魏文珑，孙建军，周宇涵，黄雪. 含氯精细化学品. 北京：化学工业出版社，2010-08-01. （“十一五国家重点图书”）