基本情况

何凤田，第三军医大学基础部生物化学与分子生物学教研室主任、教授、博士生导师。

 

教育背景

1998年至2000年 博士后，第四军医大学博士后

1991年至1997年 硕士、博士，第三军医大学硕士和博士学位

1984年至1989年 学士，第三军医大学医疗专业

 

研究领域

  1. 核受体与基因表达调控
  2. 肿瘤治疗学

 

论文发表

  1. Zhang Y, Gong W, Dai S, Huang G, Shen X, Gao M, Xu Z, Zeng Y, He F*. Downregulation of Human Farnesoid X Receptor by miR-421 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells. Mol Cancer Res. 2012, 10(4): 516-522
  2. Zhao Y, Li Y, Lou G, Zhao L, Xu Z, Zhang Y, He F*. MiR-137 Targets Estrogen-Related Receptor Alpha and Impairs the Proliferative and Migratory Capacity of Breast Cancer Cells. PloS One. 2012, 7(6): e39102
  3. Lian J, Ni Z, Dai X, Su C, Smith AR, Xu L, He F*. Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. Mol Cancer Ther. 2012, 11(2): 416-426
  4. Gao M, Zeng Y, Guan Y, Hu Z, Zhong D, Shen X, Zhang L, Xu Z, Gong W, Zhang Y, Zhang M, Zheng Y, He F*. Activation of liver X receptor attenuates endothelin-1 expression in vascular endothelial cells. Int J Biochem Cell Biol. 2012, 44(12): 2299-2307
  5. Xu Z, Huang G, Gong W, Zhou P, Zhao Y, Zhang Y, Zeng Y, Gao M, Pan Z, He F*. FXR ligands protect against hepatocellular inflammation via SOCS3 induction. Cell Signal. 2012, 24(8): 1658-1664
  6. Xu Z, Huang G, Gong W, Zhao Y, Zhou P, Zeng Y, He F*. Activation of Farnesoid X Receptor Increases the Expression of Cytokine Inducible SH2-Containing Protein in HepG2 Cells. J Interferon Cytokine Res. 2012, 32(11): 517-523
  7. Fan JS, Liu DN, Huang G, Xu ZZ, Jia Y, Zhang HG, Li XH, He FT*. Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression. J Ethnopharmacol. 2012, 142(3): 732-738
  8. Huang G, Xu Z, Huang Y, Duan X, Gong W, Zhang Y, Fan J, He F*. Curcumin Protects Against Collagen-Induced Arthritis via Suppression of BAFF Production. J Clin Immunol. 2012 Nov. 27 [Epub ahead of print]
  9. Liu D, Zhou P, Zhang L, Zheng Y, He F*. HPV16 activates the promoter of Oct4 gene by sequestering HDAC1 from repressor complex to target it to proteasomal degradation. Med Hypotheses. 2012, 79(4): 531-534
  10. Liu D, Zhou P, Zhang L, Gong W, Huang G, Zheng Y, He F*. HDAC1/DNMT3A-Containing Complex Is Associated with Suppression of Oct4 inCervical Cancer Cells. Biochemistry (Mosc). 2012, 77(8): 934-940
  11. Zhang L, Jiang Y, Zheng Y, Zeng Y, Yang Z, Huang G, Liu D, Gao M, Shen X, Wu G, Yan X, He F*. Selective killing of Burkitt's lymphoma cells by mBAFF-targeted delivery of PinX1. Leukemia. 2011, 25(2): 331-340
  12. Liu D, Zhou P, Zhang L, Wu G, Zheng Y, He F*. Differential expression of Oct4 inHPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase3A. Tumour Biol.. 2011, 32(5): 941-950
  13. Gao M, Hu Z, Zheng Y, Zeng Y, Shen X, Zhong D, He F*. PPARγ Agonist Troglitazone Inhibits HMGB1 Expression in Endothelial Cells via Suppressing Transcriptional Activity of NF-κB and AP-1. Shock. 2011, 36(3): 228-234
  14. Li J, Li G, Hu JL, Fu XH, Zeng YJ, Zhou YG, Xiong G, Yang N, Dai SS, He FT*. Chronic or high dose acute caffeine treatment protects mice against oleic acid-induced acute lung injury via an adenosine A(2A) receptor-independent mechanism. Eur J Pharmacol. 2011, 654(3): 295-303
  15. Huang G, Yang Y, Xu Z, Zhou P, Gong W, Li Y, Fan J, He F*. Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-κB. Eur J Pharmacol. 2011, 650(1): 451-457
  16. Shen LL, Liu H, Peng J, Gan L, Lu L, Zhang Q, Li L, He F*, Jiang Y. Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase. Mol Biol Rep. 2011, 38(1): 553-559
  17. 17.Chao F, Gong W, Zheng Y, Li Y, Huang G, Gao M, Li J, Kuruba R, Gao X, Li S, He F*. Upregulation of scavenger receptor class B type I expression by activation of FXR in hepatocyte. Atherosclerosis. 2010, 213(2): 443-448
  18. Li Y, Gong W, Zhang L, Huang G, Li J, Shen X, He F*. Expression and purification of the fusion protein HMGB1Abox-TMD1, a novel HMGB1 antagonist. Biochemistry (Mosc). 2010, 75(4): 466-471
  19. Gong W, Zheng Y, Chao F, Li Y, Xu Z, Huang G, Gao X, Li S, He F*. The anti-inflammatory activity of HMGB1 Abox is enhanced when fused with C-terminal acidic tail. J Biomed Biotechnol. 2010, 2010: 915234. Epub 2010 Apr 1
  20. Gong W, Li Y, Chao F, Huang G, He F*. Amino acid residues 201-205 inC-terminal acidic tail region plays a crucial role in antibacterial activity of HMGB1. J Biomed Sci. 2009 Sep. 14, 16: 83
  21. Dai S, Zheng Y, Chen B, Gao M, Zhang Y, Zhang L, Gong W, He F*. Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells. Acta Biochim Pol. 2009, 56(4): 703-710
  22. He F, Zhang Q, Kuruba R, Gao X, Li J, Li Y, Gong W, Jiang Y, Xie W, Li S. Upregulation of decorin by FXR in vascular smooth muscle cells. Biochem Biophys Res Commun. 2008, 372(4): 746-751
  23. Zhang Q, He F, Kuruba R, Gao X, Wilson A, Li J, Billiar TR, Pitt BR, Xie W, Li S. FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovasc Res. 2008, 77(3): 560-569
  24. Zhang L, Gao H, Chen L, Wu B, Zheng Y, Liao R, Jiang Y, He F*. Tumor targeting of vincristine by mBAFF-modified PEG liposomes in B lymphoma cells. Cancer Lett. 2008, 269(1): 26-36
  25. Gao H, Bian A, Zheng Y, Li R, Ji Q, Huang G, Hu D, Zhang L, Gong W, Hu Y, He F*. sBAFF mutants induce neutralizing antibodies against BAFF. FEBS Lett. 2007, 581(4): 581-586.
  26. Lian J, Dai X, Li X, He F*. Identification of an active site on the laminin alpha4 chain globular domain that binds to alphavbeta3 integrin and promotes angiogenesis. Biochem Biophys Res Commun. 2006, 347(1): 248-253
  27. Gao H, Fu W, Li R, Chen L, Ji Q, Zhang L, Huang G, He F*. Expression and purification of a soluble B lymphocyte stimulator mutant modified with the T-helper cell epitope. Biotechnol Lett. 2006, 28(20): 1649-1654
  28. He F, Li J, Mu Y, Kuruba R, Ma Z, Wilson A, Alber S, Jiang Y, Stevens T, Watkins S, Pitt B, Xie W, Li S. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circ Res. 2006, 98(2): 192-199