基本情况

孙金鹏，博士，山东大学医学院生化与分子生物学研究所教授，齐鲁青年学者，山东省立医院，兼职教授。

 

研究领域

膜蛋白和酶学

 

论文发表

  1. Sun JP, Li R, Ren HZ, Xu AT, Yu X, Xu ZG. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. 2012 Nov 20. [Epub ahead of print] PMID: 23180093
  2. Xiao P, Yang L, Zhang C, Wang JY, Sun JP. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PROG BIOCHEM BIOPHYS 2012, 39(11): 1050-1060
  3. Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q,  Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE 2012; 7(8): e43631. Epub 2012 Aug 27
  4. Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP  Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. 2012 Oct; 48(2): 456-63
  5. Dou HQ, Xu YF, Sun JP,Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X  Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells Am J Physiol Cell Physiol; 302(5): C796-803
  6. Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor. Nature Chemical Biology. 2011 Aug 21; 7(10): 692-700
  7. Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY  Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. 2011 Sep 2; 286(35): 30526-34
  8. Chen M; Sun JP; LIU J; Yu X. Research progress of several protein tyrosine phosphatases in diabetes. Acta Physiologica Sinica. 2010 April; 25: 163-170
  9. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology. 2008 Feb; 26(2): 189-91
  10. Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Molecular Pharmacology. 2008 May; 73(5): 1333-8
  11. X Yu*, Sun JP*, Y He, X Guo, S Liu, B Zhou, A Hudmon, ZY Zhang. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.  Proc. Natl. Acad. Sci. USA. 2007 Dec; 104, 19767-19772
  12. Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. 2007 Sep 28; 282(39): 29043-51
  13. Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem. 2007 Feb 23; 282(8): 5413-9
  14. Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Proc Natl Acad Sci U S A. 2006 Apr 4; 103(14): 5326-31 
  15. Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. 2005 Sep 13; 44(36): 12009-21