基本情况

张舟，沈阳药科大学教授，硕士生导师。2008年至2012年在上海师范大学任教授。2012年至今在沈阳药科大学任教授。

 

研究领域

与神经退行性疾病有关的膜转运蛋白的生物物理学研究：神经介质转运蛋白（Na+偶联的中性氨基酸转运蛋白SNAT）的分子机制和结构功能的研究

 

论文发表

  1. Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A. Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter. Journal of Biological Chemistry. 2012, 287(32): 26921-31 (SCI 5.33)
  2. Zhang J., Xiao Y., Guo Y., Brelin P., Zhang S., Wei W., Zhang Z*., Zhang J*. Differential requirements for C-Myc in Chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice. Leukemia. 2011 Dec; 25(12): 1857-68
  3. Zhang Z., Zander CB, Grewr C. The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. Biochem J.. 2011, 434(2): 287-96 (SCI 5.16)
  4. Zhang Z., Albers T., Fiumera HL., Gameiro A., and Grewer C. A conserved Na+ binding site of the sodium-coupled neutral amino acid transporter (SNAT2). Journal of Biological Chemistry. 2009, 284(37): 25314-26 (SCI 5.33)
  5. Grewer C., Gameiro A., Zhang Z., Tao Z., Braams S., and Rauen T. Glutamate forward and reverse uptake: From molecular mechanism to transporter-mediated release after ischemia. IUBMB Life. 2008, 60(9): 609-19 (SCI 3.58)
  6. Zhang Z., Gameiro A., and Grewer C., Highly-conserved asparagines 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. Journal of Biological Chemistry. 2008, 283(18): 12284-92 (SCI 5.33)
  7. Zhang Z., Tao Z., Gameiro A., Barcelona S., Braanms S., Rauen T., and Grewer C. Transport direction determines the kinetics of substrate transport by the glutamate transport EAAC1. Proc Natl Acad Sci U S A. 2007, 104(46): 18025-30 (SCI 9.43)
  8. Zhang Z., and Grewer C., The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophysical Journal. 2007, 92(1): 2621-32 (SCI 4.39)
  9. Zhang Z., Papageorgiou G., Corrie J. and Grewer C., Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. 2007. Biochemistry. 2007, 46(12): 3872-80 (SCI 3.22)
  10. Tao Z., Zhang Z. and Grewer C., Neutralization of the aspartic acid residue D367, but not D454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. Journal of Biological Chemistry. 2006, 281(15): 10263-72 (SCI 5.33)
  11. Guo Z., Zhang Z., Jia X., Tang Y. and Feng Y., Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin. Acta Biochimica et Biophysica Sinica. 2005, 37(10): 673-679 (SCI 0.51)
  12. Zhang Z., Tang Y., Yao S., Zhu S. and Feng Y., Protein engineering of insulin: Two novel fast-acting insulins [B16Ala]insulin and [B26Ala]insulin. Science in China(Series C). 2003, 46(5): 474-480 (SCI 0.48)
  13. Zhang Z., Chen H., Tang Y. and Feng Y., A simple, economical method of converting gene expression products of insulin into recombinant insulin and its application. Progress in Natural Science. 2003, 13(8): 596-600 (SCI 0.44)
  14. Gou Z., Tang Y., Zhang Z. and Feng Y., Mutational analysis of the three conserved valine residues of insulin and a proposal “isotype residue”. IUBMB Life. 2001, 52(6): 309-14 (SCI 2.7)