基本情况

张双庆，中国食品药品检定研究院，博士，副研究员。

 

教育背景

2005年至2008年 博士后，美国密西西比大学和德州理工大学

2002年至2005年 博士，北京大学药学院

1999年至2002年 硕士，沈阳药科大学

1995年至1999年 学士，沈阳药科大学

 

研究领域

  1. 药物动力学与药物代谢
  2. 生物分析：采用液质联用、液相色谱、气相色谱和同位素分析等方法进行生物样品分析、药物传递系统，如片剂、脂质体、纳米粒等
  3. 毒代动力


 

论文发表

  1. Zhang SQ, Fan YM. Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics. J Chromatogr B. 2012, 907(1): 173-177
  2. Zhang SQ, Chen XH, Yu M, Sun X, Li ZG. Quantification of andrograpolide sodium bisulphite in urine after intravenous injection to rats by LC-MS/MS. J Chromatogr B. 2012, 880(1): 163-167
  3. Zhang SQ, Zhu L, Wen N, Yu M, Shen YZ, Jia Q, Li ZG, Li B. Quantification of a novel natural antioxidant (UP302) in rat plasma using ultra-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B. 2011, 879(31): 3763-3766
  4. Zhang SQ. Quantification of triamcinolone acetonide in ocular tissues after intravitreal injection to rabbit using liquid chromatography-tandem mass spectrometry. J Chromatogr B. 2011, 879(7-8): 548-552
  5. Zhang SQ, Song YN, He XH, Zhong BH, Zhang ZQ. Liquid chromatography-tandem mass spectrometry for the determination of paclitaxel in rat plasma after intravenous administration of poly(L-glutamic acid)-alanine-paclitaxel conjugate. J Pharm Biomed Anal. 2010, 51(5): 1169-1174
  6. Zhang SQ, Thorsheim HR, Penugonda S, Pillai VC, Smith QR, Mehvar R. Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug. J Chromatogr B. 2009, 877(10): 927-932
  7. Zhang SQ, Chen GH. Determination of a novel paclitaxel derivative (NPD-103) in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2009, 23(5): 510-515
  8. Shah F, Zhang SQ*, Kandhari SP, Mukherjee P, Chittiboyina A, Avery MA, Avery BA. In vitro erythrocytic uptake studies of artemisinin and selected derivatives using LC-MS and 2D-QSAR analysis of uptake in parasitized erythrocytes. Bioorg Med Chem. 2009, 17(14): 5325-5331
  9. Zhang SQ, Vinnakota H, Jung JC, Carvalho P, Chittiboyina AG, Avery MA, Avery BA. Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra performance liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2009, 23(3): 302-307
  10. Zhang SQ, Chen GH, Rahman Z, Thumma S, Li SM, Repka MA. Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome. Drug Dev Ind Pharm. 2009, 35(1): 57-64
  11. Zhang SQ, Thumma S, Chen GH, Deng WB, Repka MA, Li SM. In vitro and in vivo evaluation of tegaserod maleate pH-dependant tablets. Eur J Pharm Biopharm. 2008, 69(1): 247-254
  12. Zhang SQ, Chen GH. LC-tandem-MS development and validation for the determination of tegaserod in beagle dog plasma and its application to a pharmacokinetic study. Chromatographia. 2008, 67(9-10): 801-806
  13. Zhang SQ, Chen GH. Determination of paclitaxel in human plasma by UPLC-MS-MS. J Chromatogr Sci. 2008, 46(3): 220-224
  14. Zhang SQ, Zhong XY, Chen GH, Lu WL, Zhang Q. The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats. J Pharm Pharmacol. 2008, 60(1): 99-105
  15. Zhang SQ, Chittiboyina AG, Kulkarni SJ, Avery MA, Avery BA. High-performance liquid chromatographic method for the determination of a novel synthetic thiazolidinedione (BP-1107) in rat plasma and its application to a pharmacokinetic study. Chromatographia. 2008, 68(7-8): 551-555
  16. Murthy SN, Zhang SQ. Electroporation and transcutaneous sampling (ETS) of acyclovir. J Dermatol Sci. 2008, 49(3): 249-251
  17. Thumma S, Zhang SQ, Repka MA. Development and validation of a HPLC method for the analysis of promethazine hydrochloride in hot-melt extruded dosage forms. Pharmazie. 2008, 63(8): 562-567
  18. Thumma S, ElSohly MA, Zhang SQ, Gul W, Repka MA. Influence of plasticizers on the stability and release of a pro-drug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices. Eur J Pharm Biopharm. 2008, 70(2): 605-614
  19. Rahman Z, Kohli K, Zhang SQ, Khar RK, Ali M, Charoo NA, Tauseef M, Shamsher AAA, Naqvi NM, Repka MA. In-vivo evaluation of colon-specific microspheres formulation containing 5-fluorouracil in rats. J Pharm Pharmacol. 2008, 60(5): 615-623
  20. Zhang SQ, Chen GH, Lu WL, Zhang Q. Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats. J Bone Miner Metab. 2007, 25(5): 293-301
  21. Zhang SQ, Zhong XY, Lu WL, Zheng L, Zhang X, Sun F, Fu GY, Zhang Q. Pharmacodynamics and pharmacokinetics of the insulin-mimetic agent vanadyl acetylacetonate in non-diabetic and diabetic rats. J Inorg Biochem. 2005, 99(5): 1064-1075
  22. Cui CY, Lu WL, Xiao L, Zhang SQ, Huang YB, Li SL, Zhang RJ, Wang GL, Zhang X, Zhang Q. Sublingual delivery of insulin: effects of enhancers on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity. Biol Pharm Bull. 2005, 28(12): 2279-2288