标题:
FGF21对慢性–急性酒精性肝损伤的保护作用The Protection of FGF21 on Chronic-Binge Alcohol-Induced Liver Injury
作者:
许韵宇, 左伟, 谢龙腾, 邱国仕, 蒋永生, 艾为明, 林虹, 刘彦隆
关键字:
酒精肝, 成纤维细胞生长因子21Alcoholic Liver Disease, Fibroblast Growth Factor 21
期刊名称:
《Open Journal of Natural Science》, Vol.4 No.4, 2016-11-28
摘要:
本文探讨成纤维细胞生长因子21(FGF21)对慢性–急性酒精性肝损伤的保护作用。酒精处理组用慢性–急性酒精处理诱导小鼠肝损伤模型，FGF21保护组在喂酒精饮食的同时每天注射FGF21 (1 mg/kg)。12天后检测各组小鼠肝脏甘油三脂的含量以及外周血中ALT,AST,甘油三脂，游离脂肪酸和甘油的含量。结果发现FGF21可以显著抑制酒精诱导的肝脏脂肪堆积和肝损伤。表明FGF21对慢–急性酒精诱导的肝脏损伤有保护作用。
The aim is to investigate the role of FGF21 on chronic-binge alcohol-induced liver injury. Alcohol treatment group was made by chronic-binge alcohol treatment on mice and FGF21 treatment group was made by above alcohol treatment and FGF21 (1 mg/kg) injection daily. Liver triglyceride and plasma ALT, AST, triglyceride, FFA and glycerol were measured 12 days later. Results showed that FGF21 significantly inhibited alcohol-induced fat accumulation and liver injury, which indicated that FGF21 played a protection role on chronic-binge alcohol-induced liver injury.