标题:
ISW2缺失下基因功能对核小体定位影响的研究The Impact of Gene Function on Nucleosome Positioning in the Absence of ISW2
作者:
胡焕, 丰继华, 魏恨恨, 周晓雯, 李泽华
关键字:
核小体定位, 基因功能(GO), ISW2, 野生型, 富营养培养Nucleosome Positioning, Gene Ontology, ISW2, WT, YPD
期刊名称:
《Biophysics》, Vol.3 No.4, 2016-01-29
摘要:
为研究染色质重塑因子对核小体定位的影响以及ISW2缺失情况下基因功能对核小体形成的作用，本文分别对ISW2敲除、野生型(WT)及富营养培养条件下(YPD)三种酵母核小体占位率数据进行聚类、比较、分析后发现，在ISW2缺失情况下核小体的位置远离TSS，同时发现11种基因功能对核小体的定位产生了显著影响。
To study the impact of chromatin remodeling factor on nucleosome positioning and the function of gene in the formation of nucleosomes in the absence of ISW2, this paper compares and analyzes the data on the proportion of nucleosomes in three kinds of yeasts, which are cultured without ISW2, WT or in YPD. The study finds that in the absence of ISW2 the nuclesomes are far from TSS and that 11 genes impose noticeable impact on nuclesome positioning.