基于乳化–溶剂挥发法的聚合物微球可控制备及机理研究
Controllable Preparation and Mechanism Study of Polymer Microspheres Based on Emulsification-Solvent Evaporation Method
DOI: 10.12677/ms.2025.159190, PDF,   
作者: 赵童童, 董良润, 王思宁, 陈 毅*：华熙生物科技(海南)有限公司，海南 海口；海南省再生医学技术与材料转化重点实验室，海南 海口
关键词: 乳化–溶剂挥发法；聚合物微球；工艺参数调控；机理研究；生物医用材料；Emulsification-Solvent Evaporation； Polymer Microspheres； Process Parameter Modulation； Mechanistic Study； Biomedical Materials
摘要: 乳化–溶剂挥发法是聚合物微球制备领域的重要技术，其工艺参数的调控对微球的粒径分布、表面形貌和结构均一性等关键性能具有显著影响。本文系统梳理了乳化–溶剂挥发法中主要工艺参数的作用机制，重点探讨了乳化剂种类与浓度对液滴界面稳定性的影响、有机相浓度及油水比对分散效果和微球形成的调控规律，以及搅拌速率和固化温度对微球结构与性能的动态调节作用。通过厘清各因素对微球质量的影响趋势，为优化制备工艺、实现聚合物微球的可控制备提供理论依据，推动其在药物控释、生物医药及组织工程等领域的应用发展。
Abstract: Emulsification-solvent evaporation method is a significant technique in the field of polymer microsphere preparation, and the regulation of its process parameters has a pronounced impact on the critical properties of microspheres, including particle size distribution, surface morphology, and structural homogeneity. This paper systematically reviews the mechanisms of the main process parameters in emulsification-solvent evaporation, focusing on the effects of emulsifier type and concentration on the stability of droplet interfaces, the influence rules of organic phase concentration and oil-to-water ratio on dispersion and microsphere formation, as well as the dynamic regulatory effects of stirring rate and curing temperature on the structure and performance of microspheres. By clarifying the influence trends of various factors on the quality of microspheres, this study provides a theoretical foundation for optimizing the preparation process and achieving controllable preparation of polymer microspheres, thereby advancing their applications in drug-controlled release, biomedicine, and tissue engineering.
文章引用：赵童童, 董良润, 王思宁, 陈毅. 基于乳化–溶剂挥发法的聚合物微球可控制备及机理研究[J]. 材料科学, 2025, 15(9): 1783-1796. https://doi.org/10.12677/ms.2025.159190

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