莲子心中三种主要生物碱在大鼠体内代谢产物的鉴定
Identification of Metabolites of Three Main Alkaloids in Lotus Seed in Rats
摘要: 目的：对莲子心中三种生物碱在大鼠体内代谢产物的鉴定。方法：采用HPLC/Q-TOF MS法鉴定大鼠灌胃给药后不同时间尿液、粪便和脑脊液中莲子心三种生物碱的代谢产物。结果：得到三种原型药物及13种代谢产物，除了去甲基化代谢产物外，其他化合物均为首次分析鉴定得到。结论：羟基化，去甲基化，葡萄糖醛酸化及硫酸化是莲子心生物碱在大鼠体内主要的代谢途径。
Abstract: Objective: Identification of metabolites of three alkaloids in lotus seed in rats. Methods: HPLC/Q-TOF MS method was used to collect the metabolites of three alkaloids in urine, feces and cerebrospinal fluid of rats at different times after inadministration. Results: Three prototype drugs and 13 metabolites were obtained. All compounds except demethylated metabolites were identified for the first time. Conclusion: Hydroxylation, demethylation, gluconaldehyde acidification and sulfation are the main metabolic pathways of lotus heart alkaloids in rats.
文章引用：贾楠, 蒋寒蕊, 孙悦, 王欣怡, 吕晶. 莲子心中三种主要生物碱在大鼠体内代谢产物的鉴定[J]. 自然科学, 2024, 12(3): 657-665. https://doi.org/10.12677/ojns.2024.123076

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