[1]
|
Resta, F., Micheli, L., Laurino, A., et al. (2018) Selective HCN1 Block as a Strategy to Control Oxaliplatin-Induced Neuropathy. Neuropharmacology, 131, 403-413. https://doi.org/10.1016/j.neuropharm.2018.01.014
|
[2]
|
Jiang, Y.Q., Sun, Q., Tu, H.Y., et al. (2008) Characteristics of HCN Channels and Their Participation in Neuropathic Pain. Neurochemical Research, 33, 1979-1989. https://doi.org/10.1007/s11064-008-9717-6
|
[3]
|
Alcantara Montero, A., Ibor Vidal, P.J., Alonso Verdugo, A., et al. (2019) Update in the Pharmacological Treatment of Neuropathic Pain. Se-mergen, 45, 535-545. https://doi.org/10.1016/j.semerg.2019.05.008
|
[4]
|
Murnion, B.P. (2018) Neuropathic Pain: Current Definition and Review of Drug Treatment. Australian Prescriber, 41, 60-63. https://doi.org/10.18773/austprescr.2018.022
|
[5]
|
Alles, S.R.A. and Smith, P.A. (2021) Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets. Frontiers in Pain Research (Lausanne), 2, Article ID: 750583.
https://doi.org/10.3389/fpain.2021.750583
|
[6]
|
Lancon, K., Qu, C., Navratilova, E., et al. (2021) Decreased Do-paminergic Inhibition of Pyramidal Neurons in Anterior Cingulate Cortex Maintains Chronic Neuropathic Pain. Cell Re-ports, 37, Article ID: 109933.
https://doi.org/10.1016/j.celrep.2021.109933
|
[7]
|
Du, L., Wang, S.J., Cui, J., et al. (2013) Inhibition of HCN Channels within the Periaqueductal Gray Attenuates Neuropathic Pain in Rats. Behavioral Neuroscience, 127, 325-329. https://doi.org/10.1037/a0031893
|
[8]
|
Lee, M.C., Bond, S., Wheeler, D., et al. (2019) A Randomised, Dou-ble-Blind, Placebo-Controlled Crossover Trial of the Influence of the HCN Channel Blocker Ivabradine in a Healthy Volunteer Pain Model: An Enriched Population Trial. Pain, 160, 2554-2565. https://doi.org/10.1097/j.pain.0000000000001638
|
[9]
|
Rivolta, I., Binda, A., Masi, A., et al. (2020) Cardiac and Neuronal HCN Channelopathies. Pflügers Archiv, 472, 931-951. https://doi.org/10.1007/s00424-020-02384-3
|
[10]
|
Santello, M. and Nevian, T. (2015) Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation. Neuron, 86, 233-246. https://doi.org/10.1016/j.neuron.2015.03.003
|
[11]
|
Santoro, B. and Shah, M.M. (2020) Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders. Annual Review of Pharmacology and Toxicology, 60, 109-131.
https://doi.org/10.1146/annurev-pharmtox-010919-023356
|
[12]
|
Arakawa, K., Kaku, R., Kurita, M., et al. (2018) Prolonged-Duration Pulsed Radiofrequency Is Associated with Increased Neuronal Damage without Further Antiallo-dynic Effects in Neuropathic Pain Model Rats. Journal of Pain Research, 11, 2645-2651. https://doi.org/10.2147/JPR.S168064
|
[13]
|
Yang, L., Ding, W., You, Z., et al. (2019) Alleviation of Trigeminal Neuropathic Pain by Electroacupuncture: The Role of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Protein Expression in the Gasserian Ganglion. Acupuncture in Medicine, 37, 192-198. https://doi.org/10.1177/0964528419841614
|
[14]
|
Hsiao, H.T., Liu, Y.C., Liu, P.Y., et al. (2019) Concerted Sup-pression of Ih and Activation of IK(M) by Ivabradine, an HCN-Channel Inhibitor, in Pituitary Cells and Hippocampal Neurons. Brain Research Bulletin, 149, 11-20.
https://doi.org/10.1016/j.brainresbull.2019.03.016
|
[15]
|
He, J.T., Li, X.Y., Zhao, X., et al. (2019) Hyperpolariza-tion-Activated and Cyclic Nucleotide-Gated Channel Proteins as Emerging New Targets in Neuropathic Pain. Reviews in the Neurosciences, 30, 639-649.
https://doi.org/10.1515/revneuro-2018-0094
|
[16]
|
Jiang, Y.Q., Xing, G.G., Wang, S.L., et al. (2008) Axonal Ac-cumulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels Contributes to Mechanical Allo-dynia after Peripheral Nerve Injury in Rat. Pain, 137, 495-506. https://doi.org/10.1016/j.pain.2007.10.011
|
[17]
|
Emery, E.C., Young, G.T., Berrocoso, E.M., et al. (2011) HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain. Science, 333, 1462-1466. https://doi.org/10.1126/science.1206243
|
[18]
|
Yang, Y., Xia, Z., Meng, Q., et al. (2018) Dexmedetomidine Relieves Neuropathic Pain by Inhibiting Hyperpolarization-Activated Cyclic Nucleotide-Gated Currents in Dorsal Root Ganglia Neurons. Neuroreport, 29, 1001-1006.
https://doi.org/10.1097/WNR.0000000000001068
|
[19]
|
Bernal, L. and Roza, C. (2018) Hyperpolarization-Activated Channels Shape Temporal Patterns of Ectopic Spontaneous Discharge in C-Nociceptors after Peripheral Nerve Injury. European Journal of Pain, 22, 1377-1387.
https://doi.org/10.1002/ejp.1226
|
[20]
|
Tsantoulas, C., Mooney, E.R. and McNaughton, P.A. (2016) HCN2 Ion Channels: Basic Science Opens up Possibilities for Therapeutic Intervention in Neuropathic Pain. Biochemical Journal, 473, 2717-2736.
https://doi.org/10.1042/BCJ20160287
|
[21]
|
Cordeiro Matos, S., Zhang, Z. and Seguela, P. (2015) Peripheral Neu-ropathy Induces HCN Channel Dysfunction in Pyramidal Neurons of the Medial Prefrontal Cortex. Journal of Neuro-science, 35, 13244-13256.
https://doi.org/10.1523/JNEUROSCI.0799-15.2015
|
[22]
|
Balducci, V., Credi, C., Sacconi, L., et al. (2021) The HCN Channel as a Pharmacological Target: Why, Where, and How to Block It. Progress in Biophysics and Molecular Biology, 166, 173-181.
https://doi.org/10.1016/j.pbiomolbio.2021.07.010
|
[23]
|
Blom, S.M., Pfister, J.P., Santello, M., et al. (2014) Nerve Injury-Induced Neuropathic Pain Causes Disinhibition of the Anterior Cingulate Cortex. Journal of Neuroscience, 34, 5754-5764.
https://doi.org/10.1523/JNEUROSCI.3667-13.2014
|
[24]
|
Ma, Y., Chen, J., Yu, D., et al. (2021) cAMP-PKA Sig-naling Is Involved in Regulation of Spinal HCN Channels Function in Diabetic Neuropathic Pain. Neuroscience Letters, 750, Article ID: 135763.
https://doi.org/10.1016/j.neulet.2021.135763
|
[25]
|
Cordeiro Matos, S., Zamfir, M., Longo, G., et al. (2018) Nora-drenergic Fiber Sprouting and Altered Transduction in Neuropathic Prefrontal Cortex. Brain Structure and Function, 223, 1149-1164.
https://doi.org/10.1007/s00429-017-1543-7
|
[26]
|
Wan, Y. (2008) Involvement of Hyperpolarization-Activated, Cy-clic Nucleotide-Gated Cation Channels in Dorsal Root Ganglion in Neuropathic Pain. Acta Physiologica Sinica, 60, 579-580.
|
[27]
|
Santello, M., Bisco, A., Nevian, N.E., et al. (2017) The Brain-Penetrant 5-HT7 Receptor Agonist LP-211 Reduces the Sensory and Affective Components of Neuropathic Pain. Neurobiology of Disease, 106, 214-221.
https://doi.org/10.1016/j.nbd.2017.07.005
|
[28]
|
Liu, X., Zhang, L., Jin, L., et al. (2018) HCN2 Contributes to Ox-aliplatin-Induced Neuropathic Pain through Activation of the CaMKII/CREB Cascade in Spinal Neurons. Molecular Pain, 14.
https://doi.org/10.1177/1744806918778490
|
[29]
|
Ma, X., Du, W., Wang, W., et al. (2020) Persistent Rheb-Induced mTORC1 Activation in Spinal Cord Neurons Induces Hypersensitivity in Neuropathic Pain. Cell Death & Disease, 11, 747. https://doi.org/10.1038/s41419-020-02966-0
|
[30]
|
Gao, S.H., Wen, H.Z., Shen, L.L., et al. (2016) Activation of mGluR1 Contributes to Neuronal Hyperexcitability in the Rat Anterior Cingulate Cortex via Inhibition of HCN Chan-nels. Neuropharmacology, 105, 361-377.
https://doi.org/10.1016/j.neuropharm.2016.01.036
|
[31]
|
Cook, D.C. and Goldstein, P.A. (2021) Non-Canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels. Current Neuropharmacology, 19, 1937-1951.
https://doi.org/10.2174/1570159X19666210119153047
|
[32]
|
Bernard Healey, S.A., Scholtes, I., Abrahams, M., et al. (2021) Role of Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in Neuropathic Pain: A Proof-of-Concept Study of Ivabradine in Patients with Chronic Peripheral Neuropathic Pain. Pain Reports, 6, e967. https://doi.org/10.1097/PR9.0000000000000967
|
[33]
|
Tibbs, G.R., Rowley, T.J., Sanford, R.L., et al. (2013) HCN1 Channels as Targets for Anesthetic and Nonanesthetic Propofol Analogs in the Amelioration of Mechanical and Thermal Hyperalgesia in a Mouse Model of Neuropathic Pain. Journal of Pharmacology and Experimental Therapeutics, 345, 363-373. https://doi.org/10.1124/jpet.113.203620
|
[34]
|
Dini, L., Del Lungo, M., Resta, F., et al. (2018) Selec-tive Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy against Pain. Frontiers in Pharmacolo-gy, 9, Article No. 1252.
https://doi.org/10.3389/fphar.2018.01252
|
[35]
|
Dewar, M.B. (2019) HCN3 Has Minimal Involvement in the Sensa-tion of Acute, Inflammatory and Neuropathic Pain. The Journal of Physiology, 597, 5333-5334. https://doi.org/10.1113/JP278770
|
[36]
|
Tae, H.S., Smith, K.M., Phillips, A.M., et al. (2017) Gabapentin Modulates HCN4 Channel Voltage-Dependence. Frontiers in Pharmacology, 8, Article No. 554. https://doi.org/10.3389/fphar.2017.00554
|